RAP1GAP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.{{cite journal | vauthors = Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P | title = Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1 | journal = Cell | volume = 65 | issue = 6 | pages = 1033–42 | date = June 1991 | pmid = 1904317 | doi = 10.1016/0092-8674(91)90555-D | s2cid = 45725280 }}{{cite web | title = Entrez Gene: RAP1GAP RAP1 GTPase activating protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5909}}
Interactions
RAP1GAP has been shown to interact with MLLT4.{{cite journal | vauthors = Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N | title = AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15232–8 | date = April 2003 | pmid = 12590145 | doi = 10.1074/jbc.M211888200 | doi-access = free | hdl = 2433/148462 | hdl-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Hattori M, Minato N | title = Rap1 GTPase: functions, regulation, and malignancy | journal = Journal of Biochemistry | volume = 134 | issue = 4 | pages = 479–84 | date = October 2003 | pmid = 14607972 | doi = 10.1093/jb/mvg180 }}
- {{cite journal | vauthors = Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P | title = Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis | journal = Molecular and Cellular Biology | volume = 12 | issue = 10 | pages = 4634–42 | date = October 1992 | pmid = 1406653 | pmc = 360390 | doi = 10.1128/mcb.12.10.4634 }}
- {{cite journal | vauthors = Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC | title = The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35 | journal = Cytogenetics and Cell Genetics | volume = 66 | issue = 1 | pages = 18–21 | year = 1994 | pmid = 8275700 | doi = 10.1159/000133655 }}
- {{cite journal | vauthors = Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC | title = Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 29903–8 | date = November 1996 | pmid = 8939933 | doi = 10.1074/jbc.271.47.29903 | doi-access = free }}
- {{cite journal | vauthors = Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N | title = Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 28081–8 | date = October 1997 | pmid = 9346962 | doi = 10.1074/jbc.272.44.28081 | doi-access = free }}
- {{cite journal | vauthors = Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O | title = Characterization of cDNA clones in size-fractionated cDNA libraries from human brain | journal = DNA Research | volume = 4 | issue = 5 | pages = 345–9 | date = October 1997 | pmid = 9455484 | doi = 10.1093/dnares/4.5.345 | doi-access = free }}
- {{cite journal | vauthors = Mochizuki N, Ohba Y, Kiyokawa E, Kurata T, Murakami T, Ozaki T, Kitabatake A, Nagashima K, Matsuda M | title = Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) | journal = Nature | volume = 400 | issue = 6747 | pages = 891–4 | date = August 1999 | pmid = 10476970 | doi = 10.1038/23738 | bibcode = 1999Natur.400..891M | s2cid = 204995543 }}
- {{cite journal | vauthors = Meng J, Glick JL, Polakis P, Casey PJ | title = Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36663–9 | date = December 1999 | pmid = 10593970 | doi = 10.1074/jbc.274.51.36663 | doi-access = free }}
- {{cite journal | vauthors = Berruti G | title = A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells | journal = Experimental Cell Research | volume = 257 | issue = 1 | pages = 172–9 | date = May 2000 | pmid = 10854065 | doi = 10.1006/excr.2000.4877 }}
- {{cite journal | vauthors = Kao S, Jaiswal RK, Kolch W, Landreth GE | title = Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18169–77 | date = May 2001 | pmid = 11278445 | doi = 10.1074/jbc.M008870200 | doi-access = free }}
- {{cite journal | vauthors = Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V | title = MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 36 | pages = 32490–7 | date = September 2002 | pmid = 12082090 | doi = 10.1074/jbc.M200556200 | doi-access = free }}
- {{cite journal | vauthors = Liu L, Schwartz BR, Tupper J, Lin N, Winn RK, Harlan JM | title = The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40893–900 | date = October 2002 | pmid = 12091396 | doi = 10.1074/jbc.M206208200 | doi-access = free }}
- {{cite journal | vauthors = de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL | title = The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 29468–76 | date = August 2002 | pmid = 12171996 | doi = 10.1074/jbc.M204990200 | doi-access = free | hdl = 2066/142510 | hdl-access = free }}
- {{cite journal | vauthors = Meng J, Casey PJ | title = Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43417–24 | date = November 2002 | pmid = 12198116 | doi = 10.1074/jbc.M204074200 | doi-access = free }}
- {{cite journal | vauthors = Schmitt JM, Stork PJ | title = Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43024–32 | date = November 2002 | pmid = 12221082 | doi = 10.1074/jbc.M204006200 | doi-access = free }}
- {{cite journal | vauthors = Delehanty LL, Mogass M, Gonias SL, Racke FK, Johnstone B, Goldfarb AN | title = Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation | journal = Blood | volume = 101 | issue = 5 | pages = 1744–51 | date = March 2003 | pmid = 12393469 | doi = 10.1182/blood-2002-04-1278 | doi-access = free }}
- {{cite journal | vauthors = Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA | title = cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression | journal = Blood | volume = 101 | issue = 3 | pages = 998–1006 | date = February 2003 | pmid = 12393539 | doi = 10.1182/blood-2002-06-1665 | doi-access = free }}
- {{cite journal | vauthors = Gendron L, Oligny JF, Payet MD, Gallo-Payet N | title = Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 3606–14 | date = February 2003 | pmid = 12464615 | doi = 10.1074/jbc.M202446200 | doi-access = free }}
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