RAP1GAP2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.{{cite web | title = Entrez Gene: RAP1 GTPase activating protein 2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=23108 }}
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
References
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Further reading
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- {{cite journal | vauthors = Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP | title = Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets | journal = Blood | volume = 114 | issue = 7 | pages = 1396–404 | date = August 2009 | pmid = 19528539 | doi = 10.1182/blood-2008-05-155234 | hdl = 10197/5848 | s2cid = 24339637 | hdl-access = free }}
- {{cite journal | vauthors = Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH | title = GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease | journal = BMC Cardiovascular Disorders | volume = 11 | pages = 29 | date = June 2011 | pmid = 21658281 | pmc = 3141757 | doi = 10.1186/1471-2261-11-29 | doi-access = free }}
- {{cite journal | vauthors = Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M | title = Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes | journal = Experimental Cell Research | volume = 300 | issue = 1 | pages = 84–93 | date = October 2004 | pmid = 15383317 | doi = 10.1016/j.yexcr.2004.07.011 }}
- {{cite journal | vauthors = Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F | title = p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1 | journal = Cardiovascular Research | volume = 92 | issue = 1 | pages = 149–58 | date = October 2011 | pmid = 21632882 | doi = 10.1093/cvr/cvr154 | doi-access = free }}
- {{cite journal | vauthors = Schultess J, Danielewski O, Smolenski AP | title = Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets | journal = Blood | volume = 105 | issue = 8 | pages = 3185–92 | date = April 2005 | pmid = 15632203 | doi = 10.1182/blood-2004-09-3605 | doi-access = free | hdl = 10197/5867 | hdl-access = free }}
- {{cite journal | vauthors = Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP | title = Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets | journal = The Journal of Biological Chemistry | volume = 283 | issue = 4 | pages = 2297–306 | date = January 2008 | pmid = 18039662 | doi = 10.1074/jbc.M706825200 | s2cid = 20190382 | url = http://researchrepository.ucd.ie/bitstream/10197/5865/1/RG2-1433-JBC_revision_final.pdf | doi-access = free }}
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