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RASD2

{{Redirect|Rhes|rhe as in viscosity|Viscosity#Measurement}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.{{cite journal | vauthors = St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW | title = Genes expressed in human tumor endothelium | journal = Science | volume = 289 | issue = 5482 | pages = 1197–202 |date=Aug 2000 | pmid = 10947988 | doi =10.1126/science.289.5482.1197 | bibcode = 2000Sci...289.1197S }}{{cite journal | vauthors = Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG | title = Rhes: A striatal-specific Ras homolog related to Dexras1 | journal = J Neurosci Res | volume = 57 | issue = 6 | pages = 782–8 |date=Oct 1999 | pmid = 10467249 | doi =10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9 | s2cid = 21124545 }}{{cite journal | vauthors = Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J | title = The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors | journal = Oncogene | volume = 23 | issue = 2 | pages = 559–68 |date=Jan 2004 | pmid = 14724584 | doi = 10.1038/sj.onc.1207161 | doi-access = free }}{{cite web | title = Entrez Gene: RASD2 RASD family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23551}}

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.

References

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Further reading

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  • {{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |bibcode=1999Natur.402..489D |doi-access= free }}
  • {{cite journal |vauthors=Chan SL, Monks LK, Gao H, etal |title=Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell |journal=Br. J. Pharmacol. |volume=136 |issue= 1 |pages= 31–6 |year= 2002 |pmid= 11976265 |doi= 10.1038/sj.bjp.0704680 | pmc=1762110 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B |s2cid=39457788 }}
  • {{cite journal | vauthors=Taylor JP, Jackson DA, Morgan NG, Chan SL |title=Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 809–15 |year= 2006 |pmid= 16945334 |doi= 10.1016/j.bbrc.2006.08.102 }}
  • {{cite journal |vauthors=Agretti P, De Marco G, Pinchera A, etal |title=Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells |journal=J. Endocrinol. Invest. |volume=30 |issue= 4 |pages= 279–84 |year= 2007 |pmid= 17556863 |doi= 10.1007/bf03346294|s2cid=38877975 }}

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