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RASGRF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.{{cite web | title = Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5924}}

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]{{cite web | title = Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5924}}

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.{{cite news | title = Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say| url = http://www.huffingtonpost.com/2012/12/03/binge-drinking-gene-teenage-alcohol-abuse_n_2234390.html| work=Huffington Post| date=3 December 2012}}

References

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Further reading

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  • {{cite journal |vauthors=Fam NP, Zhang LJ, Rommens JM, etal |title=Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene. |journal=Genomics |volume=39 |issue= 1 |pages= 118–20 |year= 1997 |pmid= 9027497 |doi= 10.1006/geno.1996.4484 }}
  • {{cite journal |vauthors=Fam NP, Fan WT, Wang Z, etal |title=Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1396–406 |year= 1997 |pmid= 9032266 |doi= 10.1128/mcb.17.3.1396| pmc=231864 }}
  • {{cite journal |vauthors=Fan WT, Koch CA, de Hoog CL, etal |title=The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 935–8 |year= 1998 |pmid= 9707409 |doi=10.1016/S0960-9822(07)00376-4 |s2cid=8904502 |doi-access=free |bibcode=1998CBio....8..935F }}
  • {{cite journal |vauthors=Anborgh PH, Qian X, Papageorge AG, etal |title=Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4611–22 |year= 1999 |pmid= 10373510 |doi= 10.1128/mcb.19.7.4611| pmc=84259 }}
  • {{cite journal |vauthors=Lutchman M, Kim AC, Cheng L, etal |title=Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 638–49 |year= 2002 |pmid= 11856323 |doi=10.1046/j.0014-2956.2001.02694.x |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Arozarena I, Matallanas D, Berciano MT, etal |title=Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1516–30 |year= 2004 |pmid= 14749369 |doi=10.1128/MCB.24.4.1516-1530.2004 | pmc=344182 |url=https://digital.csic.es/bitstream/10261/24623/4/Activation%20of%20H-Ras.pdf }}
  • {{cite journal |vauthors=Chen H, Suzuki M, Nakamura Y, etal |title=Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer. |journal=Oncol. Rep. |volume=15 |issue= 5 |pages= 1281–5 |year= 2006 |pmid= 16596198 |doi= 10.3892/or.15.5.1281|doi-access=free }}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
  • {{cite journal | vauthors=Ruiz S, Santos E, Bustelo XR |title=RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. |journal=Mol. Cell. Biol. |volume=27 |issue= 23 |pages= 8127–42 |year= 2007 |pmid= 17923690 |doi= 10.1128/MCB.00912-07 | pmc=2169177 }}

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