RBBP6

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

RBBP6 has been shown to interact with Y box binding protein 1.{{cite journal | vauthors = Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ | title = RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1 | journal = Journal of Molecular Biology | volume = 384 | issue = 4 | pages = 908–16 | date = Dec 2008 | pmid = 18851979 | doi = 10.1016/j.jmb.2008.09.060 }}

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