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RBM15

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.{{cite journal | vauthors = Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK | title = Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia | journal = Nat Genet | volume = 28 | issue = 3 | pages = 220–1 |date=Jun 2001 | pmid = 11431691 | doi = 10.1038/90054 | s2cid = 36236342 }}{{cite journal | vauthors = Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA | title = Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 10 | pages = 5776–9 |date=May 2001 | pmid = 11344311 | pmc = 33289 | doi = 10.1073/pnas.101001498 | bibcode = 2001PNAS...98.5776M | doi-access = free }}{{cite web | title = Entrez Gene: RBM15 RNA binding motif protein 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64783}}

It is an RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m6A) methylation of RNAs{{cite web | title = UniProtKB - Q96T37 (RBM15_HUMAN) | url = https://www.uniprot.org/uniprot/Q96T37 |access-date = 29 October 2018}}

References

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Further reading

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  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Hsiao HH, Yang MY, Liu YC, etal |title=RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient. |journal=Am. J. Hematol. |volume=79 |issue= 1 |pages= 43–5 |year= 2005 |pmid= 15849773 |doi= 10.1002/ajh.20298 |s2cid=30859557 |doi-access=free }}
  • {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
  • {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
  • {{cite journal |vauthors=Lindtner S, Zolotukhin AS, Uranishi H, etal |title=RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 36915–28 |year= 2007 |pmid= 17001072 |doi= 10.1074/jbc.M608745200 |doi-access= free }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}

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