RCE1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene.{{cite journal |vauthors=Otto JC, Kim E, Young SG, Casey PJ | title = Cloning and characterization of a mammalian prenyl protein-specific protease | journal = J Biol Chem | volume = 274 | issue = 13 | pages = 8379–82 |date=Apr 1999 | pmid = 10085068 | doi =10.1074/jbc.274.13.8379 | doi-access = free }}{{cite journal |vauthors=Freije JM, Blay P, Pendas AM, Cadinanos J, Crespo P, Lopez-Otin C | title = Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins | journal = Genomics | volume = 58 | issue = 3 | pages = 270–80 |date=Jul 1999 | pmid = 10373325 | doi = 10.1006/geno.1999.5834 }}{{cite web | title = Entrez Gene: RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9986}}
This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | author=Plummer LJ |title=Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4596–605 |year= 2006 |pmid= 16361710 | pmc=2937830 |doi= 10.1074/jbc.M506284200 |name-list-style=vanc| author2=Hildebrandt ER | author3=Porter SB | display-authors=3 | last4=Rogers | first4=VA | last5=McCracken | first5=J | last6=Schmidt | first6=WK |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Bergo MO |title=On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4729–36 |year= 2004 |pmid= 14625273 |doi= 10.1074/jbc.M310081200 |name-list-style=vanc| author2=Lieu HD | author3=Gavino BJ | display-authors=3 | last4=Ambroziak | first4=P | last5=Otto | first5=JC | last6=Casey | first6=PJ | last7=Walker | first7=QM | last8=Young | first8=SG | doi-access=free }}
- {{cite journal | author=Maske CP |title=A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation |journal=J. Cell Biol. |volume=162 |issue= 7 |pages= 1223–32 |year= 2003 |pmid= 14504265 |doi= 10.1083/jcb.200303113 | pmc=2173957 |name-list-style=vanc| author2=Hollinshead MS | author3=Higbee NC | display-authors=3 | last4=Bergo | first4=MO | last5=Young | first5=SG | last6=Vaux | first6=DJ }}
- {{cite journal |vauthors=Hollander IJ, Frommer E, Aulabaugh A, Mallon R |title=Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides |journal=Biochim. Biophys. Acta |volume=1649 |issue= 1 |pages= 24–9 |year= 2003 |pmid= 12818187 |doi= 10.1016/s1570-9639(03)00150-x}}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Hollander I, Frommer E, Mallon R |title=Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides |journal=Anal. Biochem. |volume=286 |issue= 1 |pages= 129–37 |year= 2000 |pmid= 11038283 |doi= 10.1006/abio.2000.4795 }}
{{refend}}
{{gene-11-stub}}