RCP9

{{short description|Protein-coding gene in the species Homo sapiens}}

DNA-directed RNA polymerase III subunit RPC9 is an enzyme that in humans is encoded by the CRCP gene.{{cite journal | vauthors = Luebke AE, Dahl GP, Roos BA, Dickerson IM | title = Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 8 | pages = 3455–60 |date=Jun 1996 | pmid = 8622957 | pmc = 39630 | doi =10.1073/pnas.93.8.3455 | doi-access = free | bibcode = 1996PNAS...93.3455L }}{{cite journal | vauthors = Balkan W, Oates EL, Howard GA, Roos BA | title = Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein | journal = Endocrinology | volume = 140 | issue = 3 | pages = 1459–69 |date=Mar 1999 | pmid = 10067875 | doi =10.1210/endo.140.3.6541 | doi-access = free }}{{cite journal | vauthors = Siaut M, Zaros C, Levivier E, Ferri ML, Court M, Werner M, Callebaut I, Thuriaux P, Sentenac A, Conesa C | title = An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP | journal = Mol Cell Biol | volume = 23 | issue = 1 | pages = 195–205 |date=Dec 2002 | pmid = 12482973 | pmc = 140662 | doi =10.1128/MCB.23.1.195-205.2003 }}{{cite web | title = Entrez Gene: RCP9 calcitonin gene-related peptide-receptor component protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27297}}

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

{{cite journal |vauthors=Yallampalli C, Chauhan M, Thota CS, etal |title=Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity |journal=Trends Endocrinol. Metab. |volume=13 |issue= 6 |pages= 263–9 |year= 2003 |pmid= 12128288 |doi= 10.1016/s1043-2760(02)00563-5|s2cid=28476322 }}
{{cite journal |vauthors=Evans BN, Rosenblatt MI, Mnayer LO, etal |title=CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31438–43 |year= 2000 |pmid= 10903324 |doi= 10.1074/jbc.M005604200 |doi-access= free }}
{{cite journal | vauthors=Prado MA, Evans-Bain B, Oliver KR, Dickerson IM |title=The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction |journal=Peptides |volume=22 |issue= 11 |pages= 1773–81 |year= 2002 |pmid= 11754963 |doi=10.1016/S0196-9781(01)00517-4 |s2cid=37139980 }}
{{cite journal |vauthors=Moreno MJ, Terrón JA, Stanimirovic DB, etal |title=Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture |journal=Neuropharmacology |volume=42 |issue= 2 |pages= 270–80 |year= 2002 |pmid= 11804624 |doi=10.1016/S0028-3908(01)00176-9 |s2cid=45479910 }}
{{cite journal |vauthors=Harzenetter MD, Keller U, Beer S, etal |title=Regulation and function of the CGRP receptor complex in human granulopoiesis |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 306–12 |year= 2002 |pmid= 11937264 |doi=10.1016/S0301-472X(02)00772-5 |doi-access=free }}
{{cite journal |vauthors=Hu P, Wu S, Sun Y, etal |title=Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8044–55 |year= 2002 |pmid= 12391170 |doi=10.1128/MCB.22.22.8044-8055.2002 | pmc=134740 |url=http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Hasbak P, Saetrum Opgaard O, Eskesen K, etal |title=Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 1 |pages= 326–33 |year= 2003 |pmid= 12490608 |doi= 10.1124/jpet.102.037754 |s2cid=14045615 }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 }}
{{cite journal |vauthors=Zuccarello D, Morini E, Douzgou S, etal |title=Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism |journal=J. Endocrinol. Invest. |volume=27 |issue= 8 |pages= 760–4 |year= 2005 |pmid= 15636430 |doi= 10.1007/bf03347519|s2cid=19253890 }}
{{cite journal |vauthors=Krämer HH, Schmidt K, Leis S, etal |title=Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin |journal=Peptides |volume=27 |issue= 4 |pages= 917–20 |year= 2006 |pmid= 16406141 |doi= 10.1016/j.peptides.2005.08.007 |s2cid=24455456 }}

RCP9

References

Further reading