RDH11

Retinol dehydrogenase 11 is an enzyme that in humans is encoded by the RDH11 gene.{{cite journal |vauthors=Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K | title = Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina | journal = J Biol Chem | volume = 277 | issue = 47 | pages = 45537–46 |date=Nov 2002 | pmid = 12226107 | pmc = 1435693 | doi = 10.1074/jbc.M208882200 | doi-access = free }}{{cite journal |vauthors=Hara T, Harada N, Mitsui H, Miura T, Ishizaka T, Miyajima A | title = Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line | journal = Blood | volume = 84 | issue = 1 | pages = 189–99 |date=Aug 1994 | doi = 10.1182/blood.V84.1.189.189 | pmid = 8018917 | doi-access = free }}{{cite journal |vauthors=Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U | title = The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative | journal = Chem Biol Interact | volume = 178 | issue = 1–3 | pages = 94–8 |date=Feb 2009 | pmid = 19027726 | pmc = 2896744| doi = 10.1016/j.cbi.2008.10.040 | bibcode = 2009CBI...178...94P }}{{cite web | title = Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51109}}

RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens.[supplied by OMIM]

Clinical significance

Mutations in RDH11 are associated to retinitis pigmentosa.{{Cite journal

| pmid = 24916380

| year = 2014

| last1 = Xie

| first1 = Y. A.

| title = New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11

| journal = Human Molecular Genetics

| last2 = Lee

| first2 = W

| last3 = Cai

| first3 = C

| last4 = Gambin

| first4 = T

| last5 = Nõupuu

| first5 = K

| last6 = Sujirakul

| first6 = T

| last7 = Ayuso

| first7 = C

| last8 = Jhangiani

| first8 = S

| last9 = Muzny

| first9 = D

| last10 = Boerwinkle

| first10 = E

| last11 = Gibbs

| first11 = R

| last12 = Greenstein

| first12 = V. C.

| last13 = Lupski

| first13 = J. R.

| last14 = Tsang

| first14 = S. H.

| last15 = Allikmets

| first15 = R

| doi = 10.1093/hmg/ddu291

| volume=23

| issue = 21

| pages=5774–5780

| pmc=4189905

}}

References

{{cite journal | author=Lai CH |title=Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876 | author2=Chou CY | author3=Ch'ang LY | last4=Liu | first4=CS | last5=Lin | first5=W }}
{{cite journal | author=Lin B |title=Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium |journal=Cancer Res. |volume=61 |issue= 4 |pages= 1611–8 |year= 2001 |pmid= 11245473 | author2=White JT | author3=Ferguson C | last4=Wang | first4=S | last5=Vessella | first5=R | last6=Bumgarner | first6=R | last7=True | first7=LD | last8=Hood | first8=L | last9=Nelson | first9=PS }}
{{cite journal | author=Kedishvili NY |title=Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1) |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28909–15 |year= 2002 |pmid= 12036956 |doi= 10.1074/jbc.M202588200 | author2=Chumakova OV | author3=Chetyrkin SV | last4=Belyaeva | first4=OV | last5=Lapshina | first5=EA | last6=Lin | first6=DW | last7=Matsumura | first7=M | last8=Nelson | first8=PS | doi-access=free }}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Li K |title=Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus |journal=World J. Gastroenterol. |volume=9 |issue= 2 |pages= 300–3 |year= 2003 |pmid= 12532453 |doi= 10.3748/wjg.v9.i2.300| author2=Wang L | author3=Cheng J | last4=Lu | first4=YY | last5=Zhang | first5=LX | last6=Mu | first6=JS | last7=Hong | first7=Y | last8=Liu | first8=Y | last9=Duan | first9=HJ | pmc=4611333 |doi-access=free }}
{{cite journal |vauthors=Belyaeva OV, Stetsenko AV, Nelson P, Kedishvili NY |title=Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines |journal=Biochemistry |volume=42 |issue= 50 |pages= 14838–45 |year= 2004 |pmid= 14674758 |doi= 10.1021/bi035288u }}
{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal | author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 | author2=Ota T | author3=Nishikawa T | last4=Hayashi | first4=K | last5=Suzuki | first5=Y | last6=Yamamoto | first6=J | last7=Wakamatsu | first7=A | last8=Kimura | first8=K | last9=Sakamoto | first9=K | doi-access=free }}
{{cite book |vauthors=Kasus-Jacobi A, Birch DG, Anderson RE |title=Retinal Degenerative Diseases |chapter=Photoreceptor Retinol Dehydrogenases |volume=572 |pages=[https://archive.org/details/isbn_9780387284644/page/505 505–11] |pmid=17249616 |doi=10.1007/0-387-32442-9_70 |series=Advances in Experimental Medicine and Biology |date=2006 |isbn=978-0-387-28464-4 |url-access=registration |url=https://archive.org/details/isbn_9780387284644/page/505 }}
{{cite journal |vauthors=Roni V, Carpio R, Wissinger B |title=Mapping of transcription start sites of human retina expressed genes |journal=BMC Genomics |volume=8|pages= 42 |year= 2007 |pmid= 17286855 |doi= 10.1186/1471-2164-8-42 | pmc=1802077 |doi-access=free }}

RDH11

Clinical significance

References

Further reading