RECQL5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.{{cite journal | vauthors = Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A | title = Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes | journal = Genomics | volume = 54 | issue = 3 | pages = 443–52 | date = Dec 1998 | pmid = 9878247 | doi = 10.1006/geno.1998.5595 }}{{cite web | title = Entrez Gene: RECQL5 RecQ protein-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9400}}
Interactions
RECQL5 has been shown to interact with EEF1G.{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS | title = Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3762–9 | date = Sep 1999 | pmid = 10471747 | pmc = 148633 | doi = 10.1093/nar/27.18.3762 }}
- {{cite journal | vauthors = Shimamoto A, Nishikawa K, Kitao S, Furuichi Y | title = Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta | journal = Nucleic Acids Research | volume = 28 | issue = 7 | pages = 1647–55 | date = Apr 2000 | pmid = 10710432 | pmc = 102787 | doi = 10.1093/nar/28.7.1647 }}
- {{cite journal | vauthors = Garcia PL, Liu Y, Jiricny J, West SC, Janscak P | title = Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide | journal = The EMBO Journal | volume = 23 | issue = 14 | pages = 2882–91 | date = Jul 2004 | pmid = 15241474 | pmc = 514958 | doi = 10.1038/sj.emboj.7600301 }}
- {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
- {{cite journal | vauthors = Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G | title = Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers | journal = Molecular and Cellular Biology | volume = 25 | issue = 9 | pages = 3431–42 | date = May 2005 | pmid = 15831450 | pmc = 1084310 | doi = 10.1128/MCB.25.9.3431-3442.2005 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
- {{cite journal | vauthors = Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P | title = Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork | journal = Nucleic Acids Research | volume = 34 | issue = 18 | pages = 5217–31 | year = 2006 | pmid = 17003056 | pmc = 1635296 | doi = 10.1093/nar/gkl677 }}
- {{cite journal | vauthors = Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G | title = RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments | journal = Genes & Development | volume = 21 | issue = 23 | pages = 3073–84 | date = Dec 2007 | pmid = 18003859 | pmc = 2081974 | doi = 10.1101/gad.1609107 }}
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{{gene-17-stub}}