REG1B

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.

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• {{cite journal |vauthors=De Reggi M, Gharib B | title = Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions. | journal = Curr. Protein Pept. Sci. | volume = 2 | issue = 1 | pages = 19–42 | year = 2002 | pmid = 12369899 | doi = 10.2174/1389203013381233}}
• {{cite journal | vauthors = Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H | title = Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. | journal = FEBS Lett. | volume = 272 | issue = 1–2 | pages = 85–8 | year = 1990 | pmid = 2226837 | doi = 10.1016/0014-5793(90)80454-Q | s2cid = 31078322 | doi-access = free }}
• {{cite journal | vauthors = Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H | title = Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene | journal = J. Biol. Chem. | volume = 265 | issue = 13 | pages = 7432–9 | year = 1990 | doi = 10.1016/S0021-9258(19)39132-X | pmid = 2332435 | doi-access = free }}
• {{cite journal |vauthors=de la Monte SM, Ozturk M, Wands JR | title = Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain | journal = J. Clin. Invest. | volume = 86 | issue = 3 | pages = 1004–13 | year = 1990 | pmid = 2394826 | pmc = 296822 | doi = 10.1172/JCI114762}}
• {{cite journal | vauthors = De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M | title = N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue | journal = Biochim. Biophys. Acta | volume = 994 | issue = 3 | pages = 281–4 | year = 1989 | pmid = 2493268 | doi = 10.1016/0167-4838(89)90305-1 }}
• {{cite journal | vauthors = Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC | title = Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis | journal = J. Clin. Invest. | volume = 84 | issue = 1 | pages = 100–6 | year = 1989 | pmid = 2525567 | pmc = 303958 | doi = 10.1172/JCI114128 }}
• {{cite journal | author = Stewart TA | title = The human reg gene encodes pancreatic stone protein | journal = Biochem. J. | volume = 260 | issue = 2 | pages = 622–3 | year = 1989 | pmid = 2764894 | pmc = 1138718 | doi = 10.1042/bj2600622}}
• {{cite journal | vauthors = Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H | title = A novel gene activated in regenerating islets | journal = J. Biol. Chem. | volume = 263 | issue = 5 | pages = 2111–4 | year = 1988 | doi = 10.1016/S0021-9258(18)69176-8 | pmid = 2963000 | doi-access = free }}
• {{cite journal |vauthors=Rouimi P, Bonicel J, Rovery M, De Caro A | title = Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein | journal = FEBS Lett. | volume = 216 | issue = 2 | pages = 195–9 | year = 1987 | pmid = 3108036 | doi = 10.1016/0014-5793(87)80688-9| s2cid = 37809879 }}
• {{cite journal | vauthors = Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A | title = Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein | journal = Biochem. J. | volume = 238 | issue = 1 | pages = 227–32 | year = 1987 | pmid = 3541906 | pmc = 1147119 | doi = 10.1042/bj2380227}}
• {{cite journal | vauthors = De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M | title = Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice | journal = Eur. J. Biochem. | volume = 168 | issue = 1 | pages = 201–7 | year = 1987 | pmid = 3665916 | doi = 10.1111/j.1432-1033.1987.tb13405.x }}
• {{cite journal | vauthors = Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR | title = Isolation, characterization, and distribution of an unusual pancreatic human secretory protein | journal = J. Clin. Invest. | volume = 76 | issue = 6 | pages = 2115–26 | year = 1986 | pmid = 3908481 | pmc = 424321 | doi = 10.1172/JCI112216 }}
• {{cite journal | vauthors = De Reggi M, Capon C, Gharib B, Wieruszeski JM, Michel R, Fournet B | title = The glycan moiety of human pancreatic lithostathine. Structure characterization and possible pathophysiological implications | journal = Eur. J. Biochem. | volume = 230 | issue = 2 | pages = 503–10 | year = 1995 | pmid = 7607222 | doi = 10.1111/j.1432-1033.1995.tb20589.x }}
• {{cite journal | vauthors = Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL | title = Human regeneration protein/lithostathine genes map to chromosome 2p12 | journal = Ann. Hum. Genet. | volume = 57 | issue = Pt 1 | pages = 9–16 | year = 1993 | pmid = 8333731 | doi = 10.1111/j.1469-1809.1993.tb00882.x | s2cid = 19794817 }}
• {{cite journal | vauthors = Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Bergé-Lefranc JL | title = A gene homologous to the reg gene is expressed in the human pancreas | journal = FEBS Lett. | volume = 327 | issue = 3 | pages = 289–93 | year = 1993 | pmid = 8348956 | doi = 10.1016/0014-5793(93)81006-L | s2cid = 44565895 }}
• {{cite journal | vauthors = Miyashita H, Nakagawara K, Mori M, Narushima Y, Noguchi N, Moriizumi S, Takasawa S, Yonekura H, Takeuchi T, Okamoto H | title = Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12 | journal = FEBS Lett. | volume = 377 | issue = 3 | pages = 429–33 | year = 1996 | pmid = 8549770 | doi = 10.1016/0014-5793(95)01381-4 | s2cid = 5872129 | doi-access = free }}
• {{cite journal | vauthors = Bertrand JA, Pignol D, Bernard JP, Verdier JM, Dagorn JC, Fontecilla-Camps JC | title = Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation | journal = EMBO J. | volume = 15 | issue = 11 | pages = 2678–84 | year = 1996 | pmid = 8654365 | pmc = 450203 | doi = 10.1002/j.1460-2075.1996.tb00628.x}}
• {{cite journal | vauthors = Patard L, Stoven V, Gharib B, Bontems F, Lallemand JY, De Reggi M | title = What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy | journal = Protein Eng. | volume = 9 | issue = 11 | pages = 949–57 | year = 1997 | pmid = 8961348 | doi = 10.1093/protein/9.11.949 | doi-access = free }}
• {{cite journal | vauthors = Bartoli C, Baeza N, Figarella C, Pellegrini I, Figarella-Branger D | title = Expression of peptide-23/pancreatitis-associated protein and Reg genes in human pituitary and adenomas: comparison with other fetal and adult human tissues | journal = J. Clin. Endocrinol. Metab. | volume = 83 | issue = 11 | pages = 4041–6 | year = 1998 | doi = 10.1210/jcem.83.11.5217 | pmid = 9814489 | doi-access = free }}

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