RFFL
{{Short description|Protein-coding gene in the species Homo sapiens}}
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E3 ubiquitin-protein ligase RFFL (Ring Finger And FYVE Like Domain Containing E3 Ubiquitin) is a ubiquitin ligase enzyme that in humans is encoded by the RFFL gene.{{cite journal | vauthors = Coumailleau F, Das V, Alcover A, Raposo G, Vandormael-Pournin S, Le Bras S, Baldacci P, Dautry-Varsat A, Babinet C, Cohen-Tannoudji M | title = Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment | journal = Molecular Biology of the Cell | volume = 15 | issue = 10 | pages = 4444–4456 | date = October 2004 | pmid = 15229288 | pmc = 519139 | doi = 10.1091/mbc.E04-04-0274 }}{{cite web | title = Entrez Gene: RFFL ring finger and FYVE-like domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117584| access-date = }} RFFL associates with endosomes.{{cite journal | vauthors = Ravindran R, Velikkakath AK, Narendradev ND, Chandrasekharan A, Santhoshkumar TR, Srinivasula SM | title = Endosomal-associated RFFL facilitates mitochondrial clearance by enhancing PRKN/parkin recruitment to mitochondria | journal = Autophagy | volume = 18 | issue = 12 | pages = 2851–2864 | date = December 2022 | pmid = 35373701 | pmc = 9673925 | doi = 10.1080/15548627.2022.2052460 }} RFFL is known to affect cardiac repolarization,{{cite journal | vauthors = Kabakov AY, Roder K, Bronk P, Turan NN, Dhakal S, Zhong M, Lu Y, Zeltzer ZA, Najman-Licht YB, Karma A, Koren G | title = E3 ubiquitin ligase rififylin has yin and yang effects on rabbit cardiac transient outward potassium currents (Ito) and corresponding channel proteins | journal = The Journal of Biological Chemistry | volume = 300 | issue = 3 | pages = 105759 | date = March 2024 | pmid = 38367666 | doi = 10.1016/j.jbc.2024.105759 | doi-access = free | pmc = 10945274 }} Cystic fibrosis transmembrane conductance regulator (CFTR) ubiquitination,{{cite journal | vauthors = Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, Susuki-Miyata S, Miyata M, Fukuda N, Yoshida A, Xu H, Apaja PM, Lukacs GL | title = Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase | journal = Developmental Cell | volume = 44 | issue = 6 | pages = 694–708.e7 | date = March 2018 | pmid = 29503157 | pmc = 6447300 | doi = 10.1016/j.devcel.2018.02.001 }} and mitochondrial clearance by affecting Parkin/PRKN recruitment.
Interactors
See also
References
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Further reading
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- {{cite journal | vauthors = Tibbetts MD, Shiozaki EN, Gu L, McDonald ER, El-Deiry WS, Shi Y | title = Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2 | journal = Structure | volume = 12 | issue = 12 | pages = 2257–2263 | date = December 2004 | pmid = 15576038 | doi = 10.1016/j.str.2004.10.007 | doi-access = free }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–12135 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | doi-access = free | bibcode = 2004PNAS..10112130B }}
- {{cite journal | vauthors = McDonald ER, El-Deiry WS | title = Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 16 | pages = 6170–6175 | date = April 2004 | pmid = 15069192 | pmc = 395941 | doi = 10.1073/pnas.0307459101 | doi-access = free | bibcode = 2004PNAS..101.6170M }}
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