RFX4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.{{cite journal |vauthors=Emery P, Durand B, Mach B, Reith W | title = RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom | journal = Nucleic Acids Res | volume = 24 | issue = 5 | pages = 803–7 |date=May 1996 | pmid = 8600444 | pmc = 145730 | doi =10.1093/nar/24.5.803 }}{{cite journal |vauthors=Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y | title = Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members | journal = J Biol Chem | volume = 277 | issue = 1 | pages = 836–42 |date=Jan 2002 | pmid = 11682486 | doi = 10.1074/jbc.M108638200 | doi-access = free }}{{cite web | title = Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5992}}
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Dotzlaw H, Alkhalaf M, Murphy LC |title=Characterization of estrogen receptor variant mRNAs from human breast cancers |journal=Mol. Endocrinol. |volume=6 |issue= 5 |pages= 773–85 |year= 1992 |doi=10.1210/mend.6.5.1603086 |pmid= 1603086 |s2cid=25208340 |doi-access=free }}
- {{cite journal | author=Reith W |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi= 10.1128/mcb.14.2.1230| pmc=358479 |name-list-style=vanc| author2=Ucla C | author3=Barras E | display-authors=3 | last4=Gaud | first4=A | last5=Durand | first5=B | last6=Herrero-Sanchez | first6=C | last7=Kobr | first7=M | last8=Mach | first8=B }}
- {{cite journal | author=Gajiwala KS |title=Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding |journal=Nature |volume=403 |issue= 6772 |pages= 916–21 |year= 2000 |pmid= 10706293 |doi= 10.1038/35002634 |name-list-style=vanc| author2=Chen H | author3=Cornille F | display-authors=3 | last4=Roques | first4=Bernard P. | last5=Reith | first5=Walter | last6=Mach | first6=Bernard | last7=Burley | first7=Stephen K. |bibcode=2000Natur.403..916G |s2cid=4425783 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Blackshear PJ |title=Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4 |journal=Development |volume=130 |issue= 19 |pages= 4539–52 |year= 2003 |pmid= 12925582 |doi= 10.1242/dev.00661 |name-list-style=vanc| author2=Graves JP | author3=Stumpo DJ | display-authors=3 | last4=Cobos | first4=I | last5=Rubenstein | first5=JL | last6=Zeldin | first6=DC | doi-access=free}}
- {{cite journal | author=Araki R |title=Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10237–42 |year= 2004 |pmid= 14701801 |doi= 10.1074/jbc.M312761200 |name-list-style=vanc| author2=Takahashi H | author3=Fukumura R | display-authors=3 | last4=Sun | first4=F | last5=Umeda | first5=N | last6=Sujino | first6=M | last7=Inouye | first7=ST | last8=Saito | first8=T | last9=Abe | first9=M | doi-access=free }}
- {{cite journal | author=Glaser B |title=Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4 |journal=Mol. Psychiatry |volume=10 |issue= 10 |pages= 920–7 |year= 2005 |pmid= 15940297 |doi= 10.1038/sj.mp.4001689 |name-list-style=vanc| author2=Kirov G | author3=Bray NJ | display-authors=3 | last4=Green | first4=E | last5=O'Donovan | first5=M C | last6=Craddock | first6=N | last7=Owen | first7=M J | doi-access=free }}
- {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal | author=Matsushita H |title=Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients |journal=Cancer Sci. |volume=96 |issue= 11 |pages= 801–9 |year= 2006 |pmid= 16271074 |doi= 10.1111/j.1349-7006.2005.00112.x |name-list-style=vanc| author2=Uenaka A | author3=Ono T | display-authors=3 | last4=Hasegawa | first4=Kosei | last5=Sato | first5=Shuichiro | last6=Koizumi | first6=Fumihito | last7=Nakagawa | first7=Kazuhiko | last8=Toda | first8=Masahiro | last9=Shingo | first9=Tetsuro |pmc=11159248 |s2cid=25967004 |url=http://ousar.lib.okayama-u.ac.jp/files/public/1/10679/20160527184719322608/O004152.pdf }}
{{refend}}
External links
- {{MeshName|RFX4+protein,+human}}
{{NLM content}}
{{Transcription factors|g1}}
Category:Transcription factors
{{gene-12-stub}}