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RGS1

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.{{cite journal | vauthors = Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD | title = A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein | journal = Biochim Biophys Acta | volume = 1216 | issue = 2 | pages = 314–6 |date=Jan 1994 | pmid = 8241276 | doi = 10.1016/0167-4781(93)90163-8}}{{cite journal | vauthors = Druey KM, Blumer KJ, Kang VH, Kehrl JH | title = Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family | journal = Nature | volume = 379 | issue = 6567 | pages = 742–6 |date=May 1996 | pmid = 8602223 | doi = 10.1038/379742a0 | bibcode = 1996Natur.379..742D | s2cid = 4362632 | url = https://zenodo.org/record/1233178 }}

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.{{cite web | title = Entrez Gene: RGS1 regulator of G-protein signalling 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5996}}

References

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Further reading

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  • {{cite journal | vauthors=Hong JX, Wilson GL, Fox CH, Kehrl JH |title=Isolation and characterization of a novel B cell activation gene. |journal=J. Immunol. |volume=150 |issue= 9 |pages= 3895–904 |year= 1993 |doi=10.4049/jimmunol.150.9.3895 |pmid= 8473738 |doi-access=free }}
  • {{cite journal | vauthors=Heximer SP, Cristillo AD, Forsdyke DR |title=Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells. |journal=DNA Cell Biol. |volume=16 |issue= 5 |pages= 589–98 |year= 1997 |pmid= 9174164 |doi=10.1089/dna.1997.16.589 }}
  • {{cite journal |vauthors=Bowman EP, Campbell JJ, Druey KM, etal |title=Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28040–8 |year= 1998 |pmid= 9774420 |doi=10.1074/jbc.273.43.28040 |doi-access=free }}
  • {{cite journal | vauthors=Denecke B, Meyerdierks A, Böttger EC |title=RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26860–8 |year= 1999 |pmid= 10480894 |doi=10.1074/jbc.274.38.26860 |doi-access=free }}
  • {{cite journal |author3-link=John R. Falck | vauthors=Popov SG, Krishna UM, Falck JR, Wilkie TM |title=Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 18962–8 |year= 2000 |pmid= 10747990 |doi= 10.1074/jbc.M001128200 |doi-access= free }}
  • {{cite journal | vauthors=Zheng B, Chen D, Farquhar MG |title=MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3999–4004 |year= 2000 |pmid= 10760272 |doi=10.1073/pnas.97.8.3999 | pmc=18131 |bibcode=2000PNAS...97.3999Z |doi-access=free }}
  • {{cite journal |vauthors=Lou X, Yano H, Lee F, etal |title=GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways |journal=Mol. Biol. Cell |volume=12 |issue= 3 |pages= 615–27 |year= 2001 |pmid= 11251075 |doi= 10.1091/mbc.12.3.615| pmc=30968 }}
  • {{cite journal |vauthors=Hoffmann M, Ward RJ, Cavalli A, etal |title=Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha |journal=J. Neurochem. |volume=78 |issue= 4 |pages= 797–806 |year= 2001 |pmid= 11520900 |doi=10.1046/j.1471-4159.2001.00479.x |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Le Y, Honczarenko M, Glodek AM, etal |title=CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2582–90 |year= 2005 |pmid= 15728464 |doi= 10.4049/jimmunol.174.5.2582|doi-access=free }}
  • {{cite journal | vauthors=Han JI, Huang NN, Kim DU, Kehrl JH |title=RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization |journal=J. Leukoc. Biol. |volume=79 |issue= 6 |pages= 1357–68 |year= 2006 |pmid= 16565322 |doi= 10.1189/jlb.1105693 |s2cid=39672919 }}
  • {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}

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