RGS11

{{Short description|Protein-coding gene in the species Homo sapiens}}

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.{{cite journal | vauthors = Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP | title = A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 22 | pages = 13307–12 |date=Nov 1998 | pmid = 9789084 | pmc = 23793 | doi =10.1073/pnas.95.22.13307 | bibcode = 1998PNAS...9513307S | doi-access = free }}{{cite web | title = Entrez Gene: RGS11 regulator of G-protein signalling 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8786| accessdate = }}

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.{{cite web | title = Entrez Gene: RGS11 regulator of G-protein signalling 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8786| accessdate = }}

References

{{cite journal |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 |bibcode=2004Natur.432..988M |s2cid=4362044 |url= https://digital.library.unt.edu/ark:/67531/metadc788092/m2/1/high_res_d/842679.pdf |doi-access= free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Sierra DA, Gilbert DJ, Householder D, etal |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 |s2cid=16065132 }}
{{cite journal |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 |doi-access=free |url=https://ora.ox.ac.uk/objects/uuid:22613537-6304-4d29-a615-54ed8742d1d7/files/m59a7d71b8fce509a066b3244bb8136a7 }}
{{cite journal |vauthors=Snow BE, Betts L, Mangion J, etal |title=Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6489–94 |year= 1999 |pmid= 10339615 |doi=10.1073/pnas.96.11.6489 | pmc=26909 |bibcode=1999PNAS...96.6489S |doi-access=free }}
{{cite journal | vauthors=Gold SJ, Ni YG, Dohlman HG, Nestler EJ |title=Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. |journal=J. Neurosci. |volume=17 |issue= 20 |pages= 8024–37 |year= 1997 |pmid= 9315921 |pmc=6793903 |doi= 10.1523/JNEUROSCI.17-20-08024.1997}}

RGS11

References

Further reading