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RGS12

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.{{cite journal |vauthors=Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J Biol Chem | volume = 273 | issue = 28 | pages = 17749–55 |date=August 1998 | pmid = 9651375 | doi =10.1074/jbc.273.28.17749 | doi-access = free }}{{cite web | title = Entrez Gene: RGS12 regulator of G-protein signalling 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002}}

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.

Interactions

RGS12 has been shown to interact with GNAI1,{{cite journal |last=Kimple |first=R J |author2=De Vries L |author3=Tronchère H |author4=Behe C I |author5=Morris R A |author6=Gist Farquhar M |author7=Siderovski D P |date=August 2001 |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity |journal=J. Biol. Chem. |volume=276 |issue=31 |pages=29275–81 | issn = 0021-9258| pmid = 11387333 |doi = 10.1074/jbc.M103208200 |doi-access=free }} GNAI3, and the kappa opioid receptor.{{cite journal |last1=Gross |first1=JD |last2=Kaski |first2=SW |last3=Schmidt |first3=KT |last4=Cogan |first4=ES |last5=Boyt |first5=KM |last6=Wix |first6=K |last7=Schroer |first7=AB |last8=McElligott |first8=ZA |last9=Siderovski |first9=DP |last10=Setola |first10=V |title=Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. |journal=Neuropsychopharmacology |date=September 2019 |volume=44 |issue=10 |pages=1728–1741 |doi=10.1038/s41386-019-0423-7 |pmid=31141817|pmc=6785087 }}

References

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Further reading

{{Refbegin | 2}}

  • {{cite journal |vauthors=Frohme M, Scharm B, Delius H, etal |title=Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. |journal=Ann. N. Y. Acad. Sci. |volume=910 |issue= 1|pages= 85–104; discussion 104–5 |year= 2000 |pmid= 10911908 |doi=10.1111/j.1749-6632.2000.tb06703.x |bibcode=2000NYASA.910...85F |s2cid=25399395 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Snow BE, Antonio L, Suggs S, etal |title=Molecular cloning and expression analysis of rat Rgs12 and Rgs14. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 770–7 |year= 1997 |pmid= 9168931 |doi= 10.1006/bbrc.1997.6537 }}
  • {{cite journal |vauthors=Chatterjee TK, Fisher RA |title=Novel alternative splicing and nuclear localization of human RGS12 gene products. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29660–71 |year= 2000 |pmid= 10869340 |doi= 10.1074/jbc.M000330200 |doi-access= free }}
  • {{cite journal |vauthors=Schiff ML, Siderovski DP, Jordan JD, etal |title=Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. |journal=Nature |volume=408 |issue= 6813 |pages= 723–7 |year= 2001 |pmid= 11130074 |doi= 10.1038/35047093 |s2cid=205011654 }}
  • {{cite journal |vauthors=Kimple RJ, De Vries L, Tronchère H, etal |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29275–81 |year= 2001 |pmid= 11387333 |doi= 10.1074/jbc.M103208200 |doi-access= free }}
  • {{cite book |vauthors=Snow BE, Brothers GM, Siderovski DP |title=G Protein Pathways, Part B: G Proteins and their Regulators |chapter=Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain |volume=344 |pages= 740–61 |year= 2002 |pmid= 11771424 |doi=10.1016/S0076-6879(02)44752-0 |series=Methods in Enzymology |isbn=978-0-12-182245-3 }}
  • {{cite journal |vauthors=Sierra DA, Gilbert DJ, Householder D, etal |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 |s2cid=16065132 }}
  • {{cite journal |vauthors=Chatterjee TK, Fisher RA |title=RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4334–45 |year= 2002 |pmid= 12024043 |doi=10.1128/MCB.22.12.4334-4345.2002 | pmc=133853 }}
  • {{cite journal |vauthors=Potocnik U, Glavac D, Ravnik-Glavac M |title=Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability. |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 48–56 |year= 2003 |pmid= 12461749 |doi= 10.1002/gcc.10141 |s2cid=30132562 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free |bibcode=2004CBio...14.1436J }}
  • {{cite journal |vauthors=Yang S, Li YP |title=RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro. |journal=J. Bone Miner. Res. |volume=22 |issue= 1 |pages= 45–54 |year= 2007 |pmid= 17042716 |doi= 10.1359/jbmr.061007 |pmc=3559086}}
  • {{Cite journal

| last1 = Gross | first1 = J. D.

| last2 = Kaski | first2 = S. W.

| last3 = Schroer | first3 = A. B.

| last4 = Wix | first4 = K. A.

| last5 = Siderovski | first5 = D. P.

| last6 = Setola | first6 = V.

| title = Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants

| journal = J. Psychopharmacol.

| volume = 32

| issue = 2

| pages = 191–203

| year = 2018

| pmid = 29364035

| pmc = 5942192 | doi=10.1177/0269881117742100

}}

  • {{Cite journal|last1=Gross|first1=Joshua D.|last2=Kaski|first2=Shane W.|last3=Schmidt|first3=Karl T.|last4=Cogan|first4=Elizabeth S.|last5=Boyt|first5=Kristen M.|last6=Wix|first6=Kim|last7=Schroer|first7=Adam B.|last8=McElligott|first8=Zoe A.|last9=Siderovski|first9=David P.|date=2019-05-29|title=Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior|journal=Neuropsychopharmacology|volume=44|issue=10|pages=1728–1741|doi=10.1038/s41386-019-0423-7|issn=1740-634X|pmid=31141817|pmc=6785087}}
  • {{cite journal |last1=Schroer |first1=AB |last2=Mohamed |first2=JS |last3=Willard |first3=MD |last4=Setola |first4=V |last5=Oestreich |first5=E |last6=Siderovski |first6=DP |title=A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation. |journal=PLOS ONE |date=2019 |volume=14 |issue=8 |pages=e0216167 |doi=10.1371/journal.pone.0216167 |pmid=31408461|pmc=6691989 |bibcode=2019PLoSO..1416167S |doi-access=free }}

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