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RGS13

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Regulator of G-protein signaling 13 (RGS13) is a protein that in humans is encoded by the RGS13 gene.{{cite journal |vauthors=Johnson EN, Druey KM | title = Functional characterization of the G protein regulator RGS13 | journal = J Biol Chem | volume = 277 | issue = 19 | pages = 16768–16774 |date=May 2002 | pmid = 11875076 | doi = 10.1074/jbc.M200751200 | doi-access = free}}{{cite web | title = Entrez Gene: RGS13 regulator of G-protein signalling 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6003}}

RGS13 is a member of R4 subfamily of the Regulator of G protein signaling (RGS) protein family, whose members have only short peptide sequences flanking the RGS domain. RGS13 suppresses the immunoglobulin E- mediated allergic responses.{{cite journal |vauthors=Bansal G, Xie Z, Rao S, Nocka KH, Druey KM | title = Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13 | journal = Nat. Immunol. | volume = 9 | issue = 1 | pages = 73–80 | year = 2008 | pmid = 18026105 | doi = 10.1038/ni1533 | pmc = 2387203 }}

RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.

References

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Further reading

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  • {{cite journal | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 | author2=Barlow KF | author3=McLay KE | last4=Kaul | first4=R. | last5=Swarbreck | first5=D. | last6=Dunham | first6=A. | last7=Scott | first7=C. E. | last8=Howe | first8=K. L. | last9=Woodfine | first9=K. |bibcode=2006Natur.441..315G | doi-access=free }}
  • {{cite journal |vauthors=Han JI, Huang NN, Kim DU, Kehrl JH |title=RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization |journal=J. Leukoc. Biol. |volume=79 |issue= 6 |pages= 1357–1368 |year= 2006 |pmid= 16565322 |doi= 10.1189/jlb.1105693 |s2cid=39672919 }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Islam TC |title=High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma |journal=Leukemia |volume=17 |issue= 9 |pages= 1880–1890 |year= 2003 |pmid= 12970790 |doi= 10.1038/sj.leu.2403057 | author2=Asplund AC | author3=Lindvall JM | last4=Nygren | first4=L | last5=Liden | first5=J | last6=Kimby | first6=E | last7=Christensson | first7=B | last8=Smith | first8=C I E | last9=Sander | first9=B | doi-access= |s2cid=4888825 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Sierra DA |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human |journal=Genomics |volume=79 |issue= 2 |pages= 177–185 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 | author2=Gilbert DJ | author3=Householder D | last4=Grishin | first4=NV | last5=Yu | first5=K | last6=Ukidwe | first6=P | last7=Barker | first7=SA | last8=He | first8=W | last9=Wensel | first9=TG |s2cid=16065132 }}
  • {{cite journal |vauthors=Druey KM, Blumer KJ, Kang VH, Kehrl JH |title=Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family |journal=Nature |volume=379 |issue= 6567 |pages= 742–746 |year= 1996 |pmid= 8602223 |doi= 10.1038/379742a0 |bibcode=1996Natur.379..742D |s2cid=4362632 |url=https://zenodo.org/record/1233178 }}

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