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RHOB

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{About|the ras homolog gene family|the Rayburn House Office Building|Rayburn House Office Building}}

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Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.{{Cite web |title=Entrez Gene: RHOB ras homolog gene family, member B |url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=388}}{{Cite journal |vauthors=Chardin P, Madaule P, Tavitian A |date=March 1988 |title=Coding sequence of human rho cDNAs clone 6 and clone 9 |journal=Nucleic Acids Research |volume=16 |issue=6 |pages=2717 |doi=10.1093/nar/16.6.2717 |pmc=336400 |pmid=3283705}}

RHOB is a member of the Rho GTP-binding protein family.{{Cite journal |vauthors=Wennerberg K, Der CJ |date=March 2004 |title=Rho-family GTPases: it's not only Rac and Rho (and I like it) |journal=Journal of Cell Science |volume=117 |issue=Pt 8 |pages=1301–12 |doi=10.1242/jcs.01118 |pmid=15020670 |doi-access=free}}

Interactions

RHOB has been shown to interact with CIT,{{Cite journal |vauthors=Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S |date=December 1995 |title=A novel partner for the GTP-bound forms of rho and rac |journal=FEBS Letters |volume=377 |issue=2 |pages=243–8 |doi=10.1016/0014-5793(95)01351-2 |pmid=8543060 |doi-access=free}} ARHGEF3,{{Cite journal |vauthors=Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K |date=November 2002 |title=XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC |journal=The Journal of Biological Chemistry |volume=277 |issue=45 |pages=42964–72 |doi=10.1074/jbc.M207401200 |pmid=12221096 |doi-access=free}} ARHGDIG{{Cite journal |vauthors=Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B |date=November 1996 |title=RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG |journal=The Journal of Biological Chemistry |volume=271 |issue=48 |pages=30366–74 |doi=10.1074/jbc.271.48.30366 |pmid=8939998 |doi-access=free}} and RHPN2.{{Cite journal |vauthors=Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I |date=December 2002 |title=Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP |url=https://dipot.ulb.ac.be/dspace/bitstream/2013/51241/3/MircescuEJB.pdf |journal=European Journal of Biochemistry |volume=269 |issue=24 |pages=6241–9 |doi=10.1046/j.1432-1033.2002.03343.x |pmid=12473120 |s2cid=23901713}}

See also

References

{{Reflist}}

Further reading

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  • {{Cite journal |vauthors=Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE |date=January 2011 |title=RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice |journal=The American Journal of Pathology |volume=178 |issue=1 |pages=245–52 |doi=10.1016/j.ajpath.2010.11.040 |pmc=3069827 |pmid=21224061}}
  • {{Cite journal |vauthors=Casey PJ, Seabra MC |date=March 1996 |title=Protein prenyltransferases |journal=The Journal of Biological Chemistry |volume=271 |issue=10 |pages=5289–92 |doi=10.1074/jbc.271.10.5289 |pmid=8621375 |doi-access=free}}
  • {{Cite journal |vauthors=Adamson P, Marshall CJ, Hall A, Tilbrook PA |date=October 1992 |title=Post-translational modifications of p21rho proteins |journal=The Journal of Biological Chemistry |volume=267 |issue=28 |pages=20033–8 |doi=10.1016/S0021-9258(19)88661-1 |pmid=1400319 |doi-access=free}}
  • {{Cite journal |vauthors=Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K |date=February 1990 |title=Chromosome localization of human ARH genes, a ras-related gene family |journal=Genomics |volume=6 |issue=2 |pages=197–203 |doi=10.1016/0888-7543(90)90557-B |pmid=2407642}}
  • {{Cite journal |vauthors=Chardin P, Madaule P, Tavitian A |date=March 1988 |title=Coding sequence of human rho cDNAs clone 6 and clone 9 |journal=Nucleic Acids Research |volume=16 |issue=6 |pages=2717 |doi=10.1093/nar/16.6.2717 |pmc=336400 |pmid=3283705}}
  • {{Cite journal |vauthors=Madaule P, Axel R |date=May 1985 |title=A novel ras-related gene family |journal=Cell |volume=41 |issue=1 |pages=31–40 |doi=10.1016/0092-8674(85)90058-3 |pmid=3888408 |s2cid=32708060}}
  • {{Cite journal |vauthors=Robertson D, Paterson HF, Adamson P, Hall A, Monaghan P |date=May 1995 |title=Ultrastructural localization of ras-related proteins using epitope-tagged plasmids |journal=The Journal of Histochemistry and Cytochemistry |volume=43 |issue=5 |pages=471–80 |doi=10.1177/43.5.7537292 |pmid=7537292 |doi-access=free}}
  • {{Cite journal |vauthors=Armstrong SA, Hannah VC, Goldstein JL, Brown MS |date=April 1995 |title=CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB |journal=The Journal of Biological Chemistry |volume=270 |issue=14 |pages=7864–8 |doi=10.1074/jbc.270.14.7864 |pmid=7713879 |doi-access=free}}
  • {{Cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |date=September 1996 |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Research |volume=6 |issue=9 |pages=791–806 |doi=10.1101/gr.6.9.791 |pmid=8889548 |doi-access=free}}
  • {{Cite journal |vauthors=Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B |date=November 1996 |title=RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG |journal=The Journal of Biological Chemistry |volume=271 |issue=48 |pages=30366–74 |doi=10.1074/jbc.271.48.30366 |pmid=8939998 |doi-access=free}}
  • {{Cite journal |vauthors=Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ |date=February 1998 |title=PRK1 is targeted to endosomes by the small GTPase, RhoB |journal=The Journal of Biological Chemistry |volume=273 |issue=9 |pages=4811–4 |doi=10.1074/jbc.273.9.4811 |pmid=9478917 |doi-access=free}}
  • {{Cite journal |vauthors=Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O |date=June 1998 |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Research |volume=5 |issue=3 |pages=169–76 |doi=10.1093/dnares/5.3.169 |pmid=9734811 |doi-access=free}}
  • {{Cite journal |vauthors=Liu JP, Jessell TM |date=December 1998 |title=A role for rhoB in the delamination of neural crest cells from the dorsal neural tube |journal=Development |volume=125 |issue=24 |pages=5055–67 |doi=10.1242/dev.125.24.5055 |pmid=9811589}}
  • {{Cite journal |vauthors=Gampel A, Parker PJ, Mellor H |date=September 1999 |title=Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB |journal=Current Biology |volume=9 |issue=17 |pages=955–8 |bibcode=1999CBio....9..955G |doi=10.1016/S0960-9822(99)80422-9 |pmid=10508588 |s2cid=9616910 |doi-access=free}}
  • {{Cite journal |vauthors=Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W |date=January 2000 |title=The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly |journal=Cell Death and Differentiation |volume=7 |issue=1 |pages=25–36 |doi=10.1038/sj.cdd.4400616 |pmid=10713718 |doi-access=free}}
  • {{Cite journal |vauthors=((Liu Ax)), Du W, Liu JP, Jessell TM, Prendergast GC |date=August 2000 |title=RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors |journal=Molecular and Cellular Biology |volume=20 |issue=16 |pages=6105–13 |doi=10.1128/MCB.20.16.6105-6113.2000 |pmc=86086 |pmid=10913192}}
  • {{Cite journal |vauthors=Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR |date=January 2001 |title=Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding |journal=The Journal of Cell Biology |volume=152 |issue=1 |pages=111–26 |doi=10.1083/jcb.152.1.111 |pmc=2193662 |pmid=11149925}}
  • {{Cite journal |vauthors=Cerniglia GJ, Bernhard EJ, Prendergast GC |date=May 2001 |title=RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=98 |issue=11 |pages=6192–7 |bibcode=2001PNAS...98.6192L |doi=10.1073/pnas.111137198 |pmc=33444 |pmid=11353846 |doi-access=free}}
  • {{Cite journal |vauthors=Diviani D, Soderling J, Scott JD |date=November 2001 |title=AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation |journal=The Journal of Biological Chemistry |volume=276 |issue=47 |pages=44247–57 |doi=10.1074/jbc.M106629200 |pmid=11546812 |doi-access=free}}
  • {{Cite journal |vauthors=Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Muñoz-Antonia T |date=March 2002 |title=RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1 |journal=The Journal of Biological Chemistry |volume=277 |issue=10 |pages=8500–7 |doi=10.1074/jbc.M104367200 |pmid=11741970 |doi-access=free}}

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{{PDB Gallery|geneid=388}}

{{GTPases}}

{{Rho family of GTPases}}

{{gene-2-stub}}