RIMS2
{{Short description|Gene of the species Homo sapiens}}
{{Infobox_gene}}
Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 |date=April 1999 | pmid = 9872452 | doi =10.1093/dnares/5.5.277 | doi-access = free }}{{cite journal | author = Fukuda M | title = Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 | journal = J Biol Chem | volume = 278 | issue = 17 | pages = 15373–80 |date=April 2003 | pmid = 12578829 | doi = 10.1074/jbc.M212341200 | doi-access = free }}{{cite web | title = Entrez Gene: RIMS2 regulating synaptic membrane exocytosis 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9699}}
Interactions
RIMS2 has been shown to interact with YWHAH,{{cite journal |last=Sun |first=Lei |author2=Bittner Mary A |author3=Holz Ronald W |date=October 2003 |title=Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus |journal=J. Biol. Chem. |volume=278 |issue=40 |pages=38301–9 |location = United States| issn = 0021-9258| pmid = 12871946 |doi = 10.1074/jbc.M212801200 |doi-access=free }} RAPGEF4,{{cite journal |last=Shibasaki |first=Tadao |author2=Sunaga Yasuhiro |author3=Fujimoto Kei |author4=Kashima Yasushige |author5=Seino Susumu |date=February 2004 |title=Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis |journal=J. Biol. Chem. |volume=279 |issue=9 |pages=7956–61 |location = United States| issn = 0021-9258| pmid = 14660679 |doi = 10.1074/jbc.M309068200 |doi-access=free }}{{cite journal |last=Kashima |first=Y |author2=Miki T |author3=Shibasaki T |author4=Ozaki N |author5=Miyazaki M |author6=Yano H |author7=Seino S |date=Dec 2001 |title=Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion |journal=J. Biol. Chem. |volume=276 |issue=49 |pages=46046–53 |location = United States| issn = 0021-9258| pmid = 11598134 |doi = 10.1074/jbc.M108378200 |doi-access=free }} and UNC13A.{{cite web|title=Protein unc-13 homolog A|url=https://www.uniprot.org/uniprot/Q9UPW8|website=UniProt}}
References
{{Reflist}}
Further reading
{{Refbegin | 2}}
- {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
- {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
- {{cite journal |vauthors=Fenster SD, Chung WJ, Zhai R, etal |title=Piccolo, a presynaptic zinc finger protein structurally related to bassoon. |journal=Neuron |volume=25 |issue= 1 |pages= 203–14 |year= 2000 |pmid= 10707984 |doi=10.1016/S0896-6273(00)80883-1 |s2cid=10177138 |doi-access=free }}
- {{cite journal |vauthors=Kashima Y, Miki T, Shibasaki T, etal |title=Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46046–53 |year= 2002 |pmid= 11598134 |doi= 10.1074/jbc.M108378200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Wang Y, Südhof TC |title=Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins( small star, filled ). |journal=Genomics |volume=81 |issue= 2 |pages= 126–37 |year= 2003 |pmid= 12620390 |doi=10.1016/S0888-7543(02)00024-1 }}
- {{cite journal |vauthors=Sun L, Bittner MA, Holz RW |title=Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38301–9 |year= 2003 |pmid= 12871946 |doi= 10.1074/jbc.M212801200 |doi-access= free }}
- {{cite journal |vauthors=Shibasaki T, Sunaga Y, Fujimoto K, etal |title=Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7956–61 |year= 2004 |pmid= 14660679 |doi= 10.1074/jbc.M309068200 |doi-access= free }}
- {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Gérard HC, Whittum-Hudson JA, Schumacher HR, Hudson AP |title=Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection. |journal=Ann. Rheum. Dis. |volume=65 |issue= 3 |pages= 321–7 |year= 2006 |pmid= 16192289 |doi= 10.1136/ard.2005.042226 | pmc=1798071 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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