RING1

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.

RING1 has been shown to interact with CBX8,{{cite journal | vauthors = Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS | title = HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties | journal = The Journal of Biological Chemistry | volume = 275 | issue = 37 | pages = 28785–92 | date = Sep 2000 | pmid = 10825164 | doi = 10.1074/jbc.M001835200 | doi-access = free }} BMI1{{cite journal | vauthors = Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP | title = RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor | journal = Molecular and Cellular Biology | volume = 17 | issue = 7 | pages = 4105–13 | date = Jul 1997 | pmid = 9199346 | pmc = 232264 | doi=10.1128/mcb.17.7.4105}}{{cite journal | vauthors = Satijn DP, Otte AP | title = RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 57–68 | date = Jan 1999 | pmid = 9858531 | pmc = 83865 | doi=10.1128/mcb.19.1.57}} and RYBP.{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}{{cite journal | vauthors = García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M | title = RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1 | journal = The EMBO Journal | volume = 18 | issue = 12 | pages = 3404–18 | date = Jun 1999 | pmid = 10369680 | pmc = 1171420 | doi = 10.1093/emboj/18.12.3404 }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Lovering R, Hanson IM, Borden KL, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJ, Trowsdale J, Freemont PS | title = Identification and preliminary characterization of a protein motif related to the zinc finger | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 6 | pages = 2112–6 | date = Mar 1993 | pmid = 7681583 | pmc = 46035 | doi = 10.1073/pnas.90.6.2112 | bibcode = 1993PNAS...90.2112L | doi-access = free }}
• {{cite journal | vauthors = Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP | title = RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor | journal = Molecular and Cellular Biology | volume = 17 | issue = 7 | pages = 4105–13 | date = Jul 1997 | pmid = 9199346 | pmc = 232264 | doi = 10.1128/mcb.17.7.4105}}
• {{cite journal | vauthors = Kikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H | title = Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes | journal = Genomics | volume = 42 | issue = 3 | pages = 422–35 | date = Jun 1997 | pmid = 9205114 | doi = 10.1006/geno.1997.4745 }}
• {{cite journal | vauthors = Satijn DP, Otte AP | title = RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 57–68 | date = Jan 1999 | pmid = 9858531 | pmc = 83865 | doi = 10.1128/mcb.19.1.57}}
• {{cite journal | vauthors = García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M | title = RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1 | journal = The EMBO Journal | volume = 18 | issue = 12 | pages = 3404–18 | date = Jun 1999 | pmid = 10369680 | pmc = 1171420 | doi = 10.1093/emboj/18.12.3404 }}
• {{cite journal | vauthors = Bárdos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS | title = HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties | journal = The Journal of Biological Chemistry | volume = 275 | issue = 37 | pages = 28785–92 | date = Sep 2000 | pmid = 10825164 | doi = 10.1074/jbc.M001835200 | doi-access = free }}
• {{cite journal | vauthors = Trimarchi JM, Fairchild B, Wen J, Lees JA | title = The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 4 | pages = 1519–24 | date = Feb 2001 | pmid = 11171983 | pmc = 29289 | doi = 10.1073/pnas.041597698 | doi-access = free }}
• {{cite journal | vauthors = Dahiya A, Wong S, Gonzalo S, Gavin M, Dean DC | title = Linking the Rb and polycomb pathways | journal = Molecular Cell | volume = 8 | issue = 3 | pages = 557–69 | date = Sep 2001 | pmid = 11583618 | doi = 10.1016/S1097-2765(01)00346-X | doi-access = free }}
• {{cite journal | vauthors = Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y | title = A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells | journal = Science | volume = 296 | issue = 5570 | pages = 1132–6 | date = May 2002 | pmid = 12004135 | doi = 10.1126/science.1069861 | bibcode = 2002Sci...296.1132O | s2cid = 34863978 }}
• {{cite journal | vauthors = Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H | title = MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation | journal = Genes to Cells | volume = 7 | issue = 8 | pages = 835–50 | date = Aug 2002 | pmid = 12167161 | doi = 10.1046/j.1365-2443.2002.00565.x | hdl = 2027.42/72663 | s2cid = 23060582 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/72663/1/j.1365-2443.2002.00565.x.pdf | hdl-access = free }}
• {{cite journal | vauthors = Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE | title = The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans | journal = Molecular and Cellular Biology | volume = 22 | issue = 17 | pages = 6070–8 | date = Sep 2002 | pmid = 12167701 | pmc = 134016 | doi = 10.1128/MCB.22.17.6070-6078.2002 }}
• {{cite journal | vauthors = Gil J, Bernard D, Martínez D, Beach D | title = Polycomb CBX7 has a unifying role in cellular lifespan | journal = Nature Cell Biology | volume = 6 | issue = 1 | pages = 67–72 | date = Jan 2004 | pmid = 14647293 | doi = 10.1038/ncb1077 | s2cid = 23315124 }}
• {{cite journal | vauthors = Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K | title = Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 105–20 | date = Feb 2004 | pmid = 15009096 | doi = 10.1111/j.1365-2443.2004.00705.x | s2cid = 21813024 | doi-access = free }}
• {{cite journal | vauthors = Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y | title = Role of histone H2A ubiquitination in Polycomb silencing | journal = Nature | volume = 431 | issue = 7010 | pages = 873–8 | date = Oct 2004 | pmid = 15386022 | doi = 10.1038/nature02985 | bibcode = 2004Natur.431..873W | s2cid = 4344378 }}
• {{cite journal | vauthors = Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H | title = The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2 | journal = FEBS Letters | volume = 579 | issue = 5 | pages = 1220–6 | date = Feb 2005 | pmid = 15710417 | doi = 10.1016/j.febslet.2005.01.022 | s2cid = 8214807 | doi-access = free | bibcode = 2005FEBSL.579.1220Q }}

{{refend}}

{{PDB Gallery|geneid=6015}}

• {{MeshName|RING1+protein,+human}}

{{NLM content}}

{{Transcription factors}}

Category:Transcription factors

{{gene-6-stub}}