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RIPK2

{{Short description|Protein-coding gene in humans}}

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{{Infobox_gene}}

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.{{cite journal |vauthors=Inohara N, del Peso L, Koseki T, Chen S, Nunez G | title = RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis | journal = J Biol Chem | volume = 273 | issue = 20 | pages = 12296–300 |date=Jun 1998 | pmid = 9575181 | doi =10.1074/jbc.273.20.12296 | doi-access = free }}{{cite journal |vauthors=Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J | title = Identification of CARDIAK, a RIP-like kinase that associates with caspase-1 | journal = Curr Biol | volume = 8 | issue = 15 | pages = 885–8 |date=Nov 1998 | pmid = 9705938 | doi =10.1016/S0960-9822(07)00352-1 | s2cid = 1235278 | doi-access = free | bibcode = 1998CBio....8..885T }}{{cite web | title = Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8767}}

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.

Interactions

RIPK2 has been shown to interact with BIRC2.{{cite journal |last=McCarthy |first=J V |author2=Ni J |author3=Dixit V M |date=Jul 1998 |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase |journal=J. Biol. Chem. |volume=273 |issue=27 |pages=16968–75 |location = UNITED STATES| issn = 0021-9258| pmid = 9642260 |doi=10.1074/jbc.273.27.16968 |doi-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Medzhitov R, Janeway C |title=Innate immune recognition: mechanisms and pathways |journal=Immunol. Rev. |volume=173 |pages= 89–97 |year= 2000 |pmid= 10719670 |doi=10.1034/j.1600-065X.2000.917309.x |s2cid=20844121 }}
  • {{cite journal |vauthors=Dufner A, Mak TW |title=CARD tricks: controlling the interactions of CARD6 with RICK and microtubules |journal=Cell Cycle |volume=5 |issue= 8 |pages= 797–800 |year= 2006 |pmid= 16582588 |doi=10.4161/cc.5.8.2635 |doi-access=free }}
  • {{cite journal |vauthors=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968–75 |year= 1998 |pmid= 9642260 |doi=10.1074/jbc.273.27.16968 |doi-access=free }}
  • {{cite journal |vauthors=Bertin J, Nir WJ, Fischer CM, etal |title=Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12955–8 |year= 1999 |pmid= 10224040 |doi=10.1074/jbc.274.19.12955 |doi-access=free }}
  • {{cite journal |vauthors=Inohara N, Koseki T, del Peso L, etal |title=Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14560–7 |year= 1999 |pmid= 10329646 |doi=10.1074/jbc.274.21.14560 |doi-access=free }}
  • {{cite journal |vauthors=Navas TA, Baldwin DT, Stewart TA |title=RIP2 is a Raf1-activated mitogen-activated protein kinase kinase |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33684–90 |year= 1999 |pmid= 10559258 |doi=10.1074/jbc.274.47.33684 |doi-access=free }}
  • {{cite journal |vauthors=Inohara N, Koseki T, Lin J, etal |title=An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27823–31 |year= 2000 |pmid= 10880512 |doi= 10.1074/jbc.M003415200 |doi-access= free }}
  • {{cite journal |vauthors=Ogura Y, Inohara N, Benito A, etal |title=Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4812–8 |year= 2001 |pmid= 11087742 |doi= 10.1074/jbc.M008072200 |doi-access= free }}
  • {{cite journal |vauthors=Lee SH, Stehlik C, Reed JC |title=Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34495–500 |year= 2001 |pmid= 11432859 |doi= 10.1074/jbc.M101415200 |doi-access= free }}
  • {{cite journal |vauthors=Khursigara G, Bertin J, Yano H, etal |title=A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2 |journal=J. Neurosci. |volume=21 |issue= 16 |pages= 5854–63 |year= 2001 |pmid= 11487608 |doi= 10.1523/JNEUROSCI.21-16-05854.2001|pmc=6763175 |doi-access=free }}
  • {{cite journal |vauthors=Andersson L, Scharin Tang M |title=Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia |journal=Cardiovasc. Res. |volume=107 |issue= 4 |pages= 478–86 |year= 2015 |pmid= 26130752 |doi=10.1093/cvr/cvv186 |doi-access=free }}
  • {{cite journal |vauthors=Druilhe A, Srinivasula SM, Razmara M, etal |title=Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins |journal=Cell Death Differ. |volume=8 |issue= 6 |pages= 649–57 |year= 2001 |pmid= 11536016 |doi= 10.1038/sj.cdd.4400881 |doi-access= free }}
  • {{cite journal |vauthors=Chin AI, Dempsey PW, Bruhn K, etal |title=Involvement of receptor-interacting protein 2 in innate and adaptive immune responses |journal=Nature |volume=416 |issue= 6877 |pages= 190–4 |year= 2002 |pmid= 11894097 |doi= 10.1038/416190a |bibcode=2002Natur.416..190C |s2cid=4405035 }}
  • {{cite journal |vauthors=Kobayashi K, Inohara N, Hernandez LD, etal |title=RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems |journal=Nature |volume=416 |issue= 6877 |pages= 194–9 |year= 2002 |pmid= 11894098 |doi= 10.1038/416194a |bibcode=2002Natur.416..194K |hdl=2027.42/62842 |s2cid=4363636 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/62842/1/416194a.pdf |hdl-access=free }}
  • {{cite journal |vauthors=Munz B, Hildt E, Springer ML, Blau HM |title=RIP2, a Checkpoint in Myogenic Differentiation |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5879–86 |year= 2002 |pmid= 12138198 |doi=10.1128/MCB.22.16.5879-5886.2002 | pmc=133983 }}
  • {{cite journal |vauthors=Yoo NJ, Park WS, Kim SY, etal |title=Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1 |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 4 |pages= 652–8 |year= 2003 |pmid= 12459189 |doi=10.1016/S0006-291X(02)02714-6 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Chen YR, Clark AC |title=Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK |journal=Biochemistry |volume=42 |issue= 20 |pages= 6310–20 |year= 2003 |pmid= 12755636 |doi= 10.1021/bi0340752 }}
  • {{cite journal |vauthors=Yiwu Y, Bo Z, Yang W, etal |title=Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis |journal=Nature Communications |volume=13 |issue= 669 |year= 2022 |pmid= 35115556 |doi= 10.1038/s41467-022-28340-6 |pmc= 8813925 |doi-access= free}}

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