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RIT1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

GTP-binding protein Rit1 is a protein that in humans is encoded by the RIT1 gene.{{cite journal | vauthors = Lee CH, Della NG, Chew CE, Zack DJ | title = Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins | journal = The Journal of Neuroscience | volume = 16 | issue = 21 | pages = 6784–94 | date = November 1996 | doi = 10.1523/JNEUROSCI.16-21-06784.1996 | pmid = 8824319 | pmc = 6579259 }}{{cite journal | vauthors = Wes PD, Yu M, Montell C | title = RIC, a calmodulin-binding Ras-like GTPase | journal = The EMBO Journal | volume = 15 | issue = 21 | pages = 5839–48 | date = November 1996 | doi = 10.1002/j.1460-2075.1996.tb00971.x | pmid = 8918462 | pmc = 452332 }}{{cite web | title = Entrez Gene: RIT1 Ras-like without CAAX 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6016}}

Function

RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM]

Clinical significance

Mutations in RIT1 are associated to Noonan syndrome.{{cite journal | vauthors = Gos M, Fahiminiya S, Poznański J, Klapecki J, Obersztyn E, Piotrowicz M, Wierzba J, Posmyk R, Bal J, Majewski J | title = Contribution of RIT1 mutations to the pathogenesis of Noonan syndrome: four new cases and further evidence of heterogeneity | journal = American Journal of Medical Genetics. Part A | volume = 164A | issue = 9 | pages = 2310–6 | date = September 2014 | pmid = 24939608 | doi = 10.1002/ajmg.a.36646 | s2cid = 2005508 }}

Interactions

RIT1 has been shown to interact with KLHL12{{cite journal | vauthors = Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K | title = BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 17 | pages = 11083–96 | date = April 2008 | pmid = 18303015 | pmc = 2431063 | doi = 10.1074/jbc.M708473200 | doi-access = free }} and Merlin.{{cite journal | vauthors = Huang J, Chen J | title = VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation | journal = Oncogene | volume = 27 | issue = 29 | pages = 4056–64 | date = July 2008 | pmid = 18332868 | doi = 10.1038/onc.2008.44 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Shao H, Kadono-Okuda K, Finlin BS, Andres DA | title = Biochemical characterization of the Ras-related GTPases Rit and Rin | journal = Archives of Biochemistry and Biophysics | volume = 371 | issue = 2 | pages = 207–19 | date = November 1999 | pmid = 10545207 | doi = 10.1006/abbi.1999.1448 }}
  • {{cite journal | vauthors = Shao H, Andres DA | title = A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 26914–24 | date = September 2000 | pmid = 10869344 | doi = 10.1074/jbc.M002241200 | doi-access = free }}
  • {{cite journal | vauthors = Hynds DL, Spencer ML, Andres DA, Snow DM | title = Rit promotes MEK-independent neurite branching in human neuroblastoma cells | journal = Journal of Cell Science | volume = 116 | issue = Pt 10 | pages = 1925–35 | date = May 2003 | pmid = 12668729 | doi = 10.1242/jcs.00401 | doi-access = free }}
  • {{cite journal | vauthors = Li JT, Liu W, Kuang ZH, Zhang RH, Chen HK, Feng QS | title = [Mutation and amplification of RIT1 gene in hepatocellular carcinoma] | journal = Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics | volume = 21 | issue = 1 | pages = 43–6 | date = February 2004 | pmid = 14767908 }}
  • {{cite journal | vauthors = Shi GX, Andres DA | title = Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades | journal = Molecular and Cellular Biology | volume = 25 | issue = 2 | pages = 830–46 | date = January 2005 | pmid = 15632082 | pmc = 543422 | doi = 10.1128/MCB.25.2.830-846.2005 }}
  • {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 | bibcode = 2005Sci...307.1621B | s2cid = 39457788 }}
  • {{cite journal | vauthors = Benmaamar R, Pagano M | title = Involvement of the SCF complex in the control of Cdh1 degradation in S-phase | journal = Cell Cycle | volume = 4 | issue = 9 | pages = 1230–2 | date = September 2005 | pmid = 16123585 | doi = 10.4161/cc.4.9.2048 | doi-access = free }}

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