RNASE1

According to the US National Library of Medicine, "This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA." Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

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• {{cite journal | vauthors = Nogués MV, Vilanova M, Cuchillo CM | title = Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites | journal = Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | volume = 1253 | issue = 1 | pages = 16–24 | date = Nov 1995 | pmid = 7492594 | doi = 10.1016/0167-4838(95)00138-k }}
• {{cite journal | vauthors = Schienman JE, Holt RA, Auerbach MR, Stewart CB | title = Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys | journal = Molecular Biology and Evolution | volume = 23 | issue = 8 | pages = 1465–79 | date = Aug 2006 | pmid = 16751256 | doi = 10.1093/molbev/msl025 | doi-access = }}
• {{cite journal | vauthors = Sakakibara R, Hashida K, Kitahara T, Ishiguro M | title = Characterization of a unique nonsecretory ribonuclease from urine of pregnant women | journal = Journal of Biochemistry | volume = 111 | issue = 3 | pages = 325–30 | date = Mar 1992 | pmid = 1587793 | doi = 10.1093/oxfordjournals.jbchem.a123757}}
• {{cite journal | vauthors = Haugg M, Schein CH | title = The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR) | journal = Nucleic Acids Research | volume = 20 | issue = 3 | pages = 612 | date = Feb 1992 | pmid = 1741299 | pmc = 310435 | doi = 10.1093/nar/20.3.612 }}
• {{cite journal | vauthors = Sakakibara R, Hashida K, Tominaga N, Sakai K, Ishiguro M, Imamura S, Ohmatsu F, Sato E | title = A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease | journal = Chemical & Pharmaceutical Bulletin | volume = 39 | issue = 1 | pages = 146–9 | date = Jan 1991 | pmid = 2049798 | doi = 10.1248/cpb.39.146 | doi-access = free }}
• {{cite journal | vauthors = Mizuta K, Awazu S, Yasuda T, Kishi K | title = Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases | journal = Archives of Biochemistry and Biophysics | volume = 281 | issue = 1 | pages = 144–51 | date = Aug 1990 | pmid = 2383019 | doi = 10.1016/0003-9861(90)90424-W }}
• {{cite journal | vauthors = Beintema JJ, Blank A, Schieven GL, Dekker CA, Sorrentino S, Libonati M | title = Differences in glycosylation pattern of human secretory ribonucleases | journal = The Biochemical Journal | volume = 255 | issue = 2 | pages = 501–5 | date = Oct 1988 | pmid = 3202829 | pmc = 1135256 }}
• {{cite journal | vauthors = Beintema JJ, Wietzes P, Weickmann JL, Glitz DG | title = The amino acid sequence of human pancreatic ribonuclease | journal = Analytical Biochemistry | volume = 136 | issue = 1 | pages = 48–64 | date = Jan 1984 | pmid = 6201087 | doi = 10.1016/0003-2697(84)90306-3 }}
• {{cite journal | vauthors = Russo N, de Nigris M, Ciardiello A, Di Donato A, D'Alessio G | title = Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease | journal = FEBS Letters | volume = 369 | issue = 2–3 | pages = 352 | date = Aug 1995 | pmid = 7649283 | doi = 10.1016/0014-5793(95)96890-G | s2cid = 45739736 }}
• {{cite journal | vauthors = Seno M, Futami J, Kosaka M, Seno S, Yamada H | title = Nucleotide sequence encoding human pancreatic ribonuclease | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1218 | issue = 3 | pages = 466–8 | date = Aug 1994 | pmid = 8049276 | doi = 10.1016/0167-4781(94)90208-9 }}
• {{cite journal | vauthors = Yasuda T, Nadano D, Takeshita H, Kishi K | title = Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases | journal = The Biochemical Journal | volume = 296 | issue = 3 | pages = 617–25 | date = Dec 1993 | pmid = 8280059 | pmc = 1137742 | doi = 10.1042/bj2960617}}
• {{cite journal | vauthors = Papageorgiou AC, Shapiro R, Acharya KR | title = Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution | journal = The EMBO Journal | volume = 16 | issue = 17 | pages = 5162–77 | date = Sep 1997 | pmid = 9311977 | pmc = 1170149 | doi = 10.1093/emboj/16.17.5162 }}
• {{cite journal | vauthors = Klink TA, Woycechowsky KJ, Taylor KM, Raines RT | title = Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A | journal = European Journal of Biochemistry | volume = 267 | issue = 2 | pages = 566–72 | date = Jan 2000 | pmid = 10632727 | doi = 10.1046/j.1432-1327.2000.01037.x | doi-access = free }}
• {{cite journal | vauthors = Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M | title = Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases | journal = Journal of Molecular Biology | volume = 303 | issue = 1 | pages = 49–60 | date = Oct 2000 | pmid = 11021969 | doi = 10.1006/jmbi.2000.4506 }}
• {{cite journal | vauthors = Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M | title = Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution | journal = Acta Crystallographica Section D | volume = 57 | issue = Pt 4 | pages = 498–505 | date = Apr 2001 | pmid = 11264578 | doi = 10.1107/S0907444901001147 | bibcode = 2001AcCrD..57..498P | url = http://journals.iucr.org/d/issues/2001/04/00/li0374/li0374.pdf }}
• {{cite journal | vauthors = Gaur D, Swaminathan S, Batra JK | title = Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 24978–84 | date = Jul 2001 | pmid = 11342552 | doi = 10.1074/jbc.M102440200 | doi-access = free }}
• {{cite journal | vauthors = Futami J, Maeda T, Kitazoe M, Nukui E, Tada H, Seno M, Kosaka M, Yamada H | title = Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups | journal = Biochemistry | volume = 40 | issue = 25 | pages = 7518–24 | date = Jun 2001 | pmid = 11412105 | doi = 10.1021/bi010248g }}
• {{cite journal | vauthors = Canals A, Pous J, Guasch A, Benito A, Ribó M, Vilanova M, Coll M | title = The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization | journal = Structure | volume = 9 | issue = 10 | pages = 967–76 | date = Oct 2001 | pmid = 11591351 | doi = 10.1016/S0969-2126(01)00659-1 | doi-access = free }}

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• [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P07998 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Ribonuclease pancreatic

{{PDB Gallery|geneid=6035}}

{{Nucleases}}

{{gene-14-stub}}