RNF123
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.{{cite web | title = Entrez Gene: RNF123 ring finger protein 123| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63891| accessdate = }}
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.{{cite web | title = Entrez Gene: RNF123 ring finger protein 123| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63891| accessdate = }} Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).
See also
References
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Further reading
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- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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- {{cite journal |vauthors=Kamura T, Hara T, Matsumoto M, etal |title=Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. |journal=Nat. Cell Biol. |volume=6 |issue= 12 |pages= 1229–35 |year= 2005 |pmid= 15531880 |doi= 10.1038/ncb1194 |s2cid=12225217 }}
- {{cite journal |vauthors=Kotoshiba S, Kamura T, Hara T, etal |title=Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17694–700 |year= 2005 |pmid= 15746103 |doi= 10.1074/jbc.M500866200 |doi-access= free }}
- {{cite journal |vauthors=Hara T, Kamura T, Kotoshiba S, etal |title=Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. |journal=Mol. Cell. Biol. |volume=25 |issue= 21 |pages= 9292–303 |year= 2005 |pmid= 16227581 |doi= 10.1128/MCB.25.21.9292-9303.2005 | pmc=1265808 }}
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- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
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