RNF139
{{Short description|Protein-coding gene in the species Homo sapiens}}
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RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.{{cite journal | vauthors = Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA | title = The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8 | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 16 | pages = 9572–7 |date=Sep 1998 | pmid = 9689122 | pmc = 21380 | doi =10.1073/pnas.95.16.9572 | bibcode = 1998PNAS...95.9572G | doi-access = free }}{{cite web | title = Entrez Gene: RNF139 ring finger protein 139| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11236| accessdate = }}
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].{{cite web | title = Entrez Gene: RNF139 ring finger protein 139| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11236| accessdate = }}
References
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Further reading
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- {{cite journal |vauthors=Poland KS, Azim M, Folsom M, etal |title=A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. |journal=Genes Chromosomes Cancer |volume=46 |issue= 9 |pages= 805–12 |year= 2007 |pmid= 17539022 |doi= 10.1002/gcc.20466 |s2cid=44344160 |doi-access=free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
- {{cite journal |vauthors=Brauweiler A, Lorick KL, Lee JP, etal |title=RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. |journal=Oncogene |volume=26 |issue= 16 |pages= 2263–71 |year= 2007 |pmid= 17016439 |doi= 10.1038/sj.onc.1210017 |doi-access= |s2cid=12979173 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gemmill RM, Bemis LT, Lee JP, etal |title=The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. |journal=Oncogene |volume=21 |issue= 22 |pages= 3507–16 |year= 2002 |pmid= 12032852 |doi= 10.1038/sj.onc.1205437 |doi-access= |s2cid=9964634 }}
- {{cite journal |vauthors=Lorick KL, Jensen JP, Fang S, etal |title=RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11364–9 |year= 1999 |pmid= 10500182 |doi=10.1073/pnas.96.20.11364 | pmc=18039 |bibcode=1999PNAS...9611364L |doi-access=free }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
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