ROCK2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene.
{{cite web
| title = Entrez Gene: Rho associated coiled-coil containing protein kinase 2
| url = https://www.ncbi.nlm.nih.gov/gene/9475
| accessdate = 2016-04-21
}}Fasudil is an inhibitor of ROCK protein.
Function
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
References
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Further reading
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- {{cite journal |vauthors=Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV |title=Kinetic mechanism for human Rho-Kinase II (ROCK-II) |journal=Biochemistry |volume=41 |issue=28 |pages=8948–53 |year=2002 |pmid=12102637 |doi= 10.1021/bi0258243}}
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External links
- {{PDBe-KB2|O75116|Human Rho-associated protein kinase 2 (ROCK2)}}
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