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RPH3A

{{Short description|Gene of the species Homo sapiens}}

{{Infobox_gene}}

Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 6 | issue = 1 | pages = 63–70 |date=July 1999 | pmid = 10231032 | doi =10.1093/dnares/6.1.63 | doi-access = free }}{{cite journal |vauthors=Inagaki N, Mizuta M, Seino S | title = Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells | journal = J Biochem | volume = 116 | issue = 2 | pages = 239–42 |date=February 1995 | pmid = 7822236 | doi = 10.1093/oxfordjournals.jbchem.a124512}}{{cite web | title = Entrez Gene: RPH3A rabphilin 3A homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22895}}

It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.{{cite journal |vauthors=Deák F, Shin OH, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC |title=Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. |journal=EMBO J. |volume=25 |issue= 12 |pages= 2856–66 |year= 2006 |pmid= 16763567 |doi=10.1038/sj.emboj.7601165 | pmc=1500841 }}

Interactions

RPH3A has been shown to interact with RAB3A,{{cite journal |last=Fukuda |first=Mitsunori |date=April 2003 |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 |journal=J. Biol. Chem. |volume=278 |issue=17 |pages=15373–80 | issn = 0021-9258| pmid = 12578829 |doi = 10.1074/jbc.M212341200 |doi-access=free }}{{cite journal |doi=10.1016/S0092-8674(00)80549-8 |last=Ostermeier |first=C |author2=Brunger A T |date=February 1999 |title=Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A |journal=Cell |volume=96 |issue=3 |pages=363–74 | issn = 0092-8674| pmid = 10025402 |s2cid=15162326 |doi-access=free }}{{cite journal |doi=10.1074/jbc.271.12.6963 |last=Weber |first=E |author2=Jilling T |author3=Kirk K L |date=March 1996 |title=Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells |journal=J. Biol. Chem. |volume=271 |issue=12 |pages=6963–71 | issn = 0021-9258| pmid = 8636125 |doi-access=free }} RAB3B and CASK.{{cite journal |doi=10.1016/S0014-5793(01)02450-4 |last=Zhang |first=Y |author2=Luan Z |author3=Liu A |author4=Hu G |date=May 2001 |title=The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins |journal=FEBS Lett. |volume=497 |issue=2–3 |pages=99–102 | issn = 0014-5793| pmid = 11377421 |s2cid=33119468 |doi-access=free |bibcode=2001FEBSL.497...99Z }}

References

{{Reflist}}

Further reading

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  • {{cite journal |vauthors=Miyazaki M, Kaibuchi K, Shirataki H, etal |title=Rabphilin-3A binds to a M(r) 115,000 polypeptide in a phosphatidylserine- and Ca(2+)-dependent manner. |journal=Brain Res. Mol. Brain Res. |volume=28 |issue= 1 |pages= 29–36 |year= 1995 |pmid= 7707875 |doi=10.1016/0169-328X(94)00180-M }}
  • {{cite journal |vauthors=Imazumi K, Sasaki T, Takahashi K, Takai Y |title=Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1409–16 |year= 1995 |pmid= 7802677 |doi= 10.1006/bbrc.1994.2822 }}
  • {{cite journal |vauthors=Miyazaki M, Shirataki H, Kohno H, etal |title=Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 460–6 |year= 1995 |pmid= 7999065 |doi= 10.1006/bbrc.1994.2688 }}
  • {{cite journal |vauthors=Mizoguchi A, Yano Y, Hamaguchi H, etal |title=Localization of Rabphilin-3A on the synaptic vesicle. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 3 |pages= 1235–43 |year= 1994 |pmid= 8060298 |doi= 10.1006/bbrc.1994.2063 }}
  • {{cite journal |vauthors=Weber E, Jilling T, Kirk KL |title=Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6963–71 |year= 1996 |pmid= 8636125 |doi=10.1074/jbc.271.12.6963 |doi-access=free }}
  • {{cite journal | author=Perin MS |title=Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin. |journal=Biochemistry |volume=35 |issue= 43 |pages= 13808–16 |year= 1996 |pmid= 8901523 |doi= 10.1021/bi960853x }}
  • {{cite journal |vauthors=Gilligan DM, Lozovatsky L, Silberfein A |title=Organization of the human beta-adducin gene (ADD2). |journal=Genomics |volume=43 |issue= 2 |pages= 141–8 |year= 1997 |pmid= 9244430 |doi= 10.1006/geno.1997.4802 |doi-access= free }}
  • {{cite journal |vauthors=Ostermeier C, Brunger AT |title=Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. |journal=Cell |volume=96 |issue= 3 |pages= 363–74 |year= 1999 |pmid= 10025402 |doi=10.1016/S0092-8674(00)80549-8 |s2cid=15162326 |doi-access=free }}
  • {{cite journal |vauthors=Zhang Y, Luan Z, Liu A, Hu G |title=The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins. |journal=FEBS Lett. |volume=497 |issue= 2–3 |pages= 99–102 |year= 2001 |pmid= 11377421 |doi=10.1016/S0014-5793(01)02450-4 |s2cid=33119468 |doi-access=free |bibcode=2001FEBSL.497...99Z }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373–80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 |doi-access= free }}
  • {{cite journal |vauthors=Sun L, Bittner MA, Holz RW |title=Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38301–9 |year= 2003 |pmid= 12871946 |doi= 10.1074/jbc.M212801200 |doi-access= free }}
  • {{cite journal |vauthors=Rastaldi MP, Armelloni S, Berra S, etal |title=Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a. |journal=Am. J. Pathol. |volume=163 |issue= 3 |pages= 889–99 |year= 2003 |pmid= 12937130 |doi= 10.1016/S0002-9440(10)63449-9| pmc=1868247 }}
  • {{cite journal |vauthors=Dalfó E, Barrachina M, Rosa JL, etal |title=Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. |journal=Neurobiol. Dis. |volume=16 |issue= 1 |pages= 92–7 |year= 2004 |pmid= 15207266 |doi= 10.1016/j.nbd.2004.01.001 |s2cid=5793677 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Smith R, Klein P, Koc-Schmitz Y, etal |title=Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. |journal=J. Neurochem. |volume=103 |issue= 1 |pages= 115–23 |year= 2007 |pmid= 17877635 |doi= 10.1111/j.1471-4159.2007.04703.x |url=https://lup.lub.lu.se/record/607693 |doi-access=free }}
  • {{cite journal |vauthors=Katkoori VR, Jia X, Chatla C, etal |title=Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma. |journal=Front. Biosci. |volume=13 |issue= 13|pages= 1050–61 |year= 2007 |pmid= 17981610 |doi=10.2741/2742 | pmc=2667692 }}

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