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RPS6KA5

{{Short description|Enzyme}}

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{{Infobox gene}}

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.{{cite journal | vauthors = Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = The EMBO Journal | volume = 17 | issue = 15 | pages = 4426–4441 | date = September 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}{{cite journal | vauthors = Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S | title = Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 3–4 | pages = 261–262 | date = April 2000 | pmid = 10702687 | doi = 10.1159/000015441 | s2cid = 10527498 }}{{cite web | title = Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9252 }} This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.{{cite journal | vauthors = Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS | title = MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 | journal = The EMBO Journal | volume = 22 | issue = 11 | pages = 2788–2797 | date = 2003-06-02 | pmid = 12773393 | pmc = 156769 | doi = 10.1093/emboj/cdg273 | issn = 0261-4189 }}{{Cite journal | vauthors = Reul JM, Chandramohan Y | title = Epigenetic mechanisms in stress-related memory formation | journal = Psychoneuroendocrinology | volume = 32 Suppl 1 | pages = S21–S25 | date = 2007-08-01 | pmid = 17644269 | doi = 10.1016/j.psyneuen.2007.03.016 | url = http://www.sciencedirect.com/science/article/pii/S0306453007001308 | series = Integrative approaches to neural plasticity (Lille Summer School, 2006) | language = en | s2cid = 24217924 | issn = 0306-4530 | url-access = subscription }}

Interactions

RPS6KA5 has been shown to interact with CREB1.{{cite journal | vauthors = Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG | title = Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase | journal = The EMBO Journal | volume = 20 | issue = 16 | pages = 4370–4379 | date = August 2001 | pmid = 11500364 | pmc = 125559 | doi = 10.1093/emboj/20.16.4370 | issn = 0261-4189 }}

References

{{Reflist}}

Further reading

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  • {{cite journal | vauthors = Chung J, Uchida E, Grammer TC, Blenis J | title = STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6508–6516 | date = Nov 1997 | pmid = 9343414 | pmc = 232504 | doi = 10.1128/MCB.17.11.6508 }}
  • {{cite journal | vauthors = Jain N, Zhang T, Fong SL, Lim CP, Cao X | title = Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK) | journal = Oncogene | volume = 17 | issue = 24 | pages = 3157–3167 | date = Dec 1998 | pmid = 9872331 | doi = 10.1038/sj.onc.1202238 | doi-access = free }}
  • {{cite journal | vauthors = New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludwig S, Padova FD, Gram H, Han J | title = Cloning and characterization of RLPK, a novel RSK-related protein kinase | journal = Journal of Biological Chemistry | volume = 274 | issue = 2 | pages = 1026–1032 | date = Jan 1999 | pmid = 9873047 | doi = 10.1074/jbc.274.2.1026 | doi-access = free }}
  • {{cite journal | vauthors = Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC | title = The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase | journal = The EMBO Journal | volume = 18 | issue = 17 | pages = 4779–4793 | date = Sep 1999 | pmid = 10469656 | pmc = 1171550 | doi = 10.1093/emboj/18.17.4779 }}
  • {{cite journal | vauthors = Lim CP, Cao X | title = Serine phosphorylation and negative regulation of Stat3 by JNK | journal = Journal of Biological Chemistry | volume = 274 | issue = 43 | pages = 31055–31061 | date = Oct 1999 | pmid = 10521505 | doi = 10.1074/jbc.274.43.31055 | doi-access = free }}
  • {{cite journal | vauthors = Buck M, Poli V, Geer P, Chojkier M, Hunter T | title = Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha | journal = Molecular Cell | volume = 4 | issue = 6 | pages = 1087–1092 | date = Dec 1999 | pmid = 10635333 | doi = 10.1016/S1097-2765(00)80237-3 | doi-access = free }}
  • {{cite journal | vauthors = Lizcano JM, Morrice N, Cohen P | title = Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155 | journal = The Biochemical Journal | volume = 349 | issue = Pt 2 | pages = 547–557 | date = Jul 2000 | pmid = 10880354 | pmc = 1221178 | doi = 10.1042/0264-6021:3490547 }}
  • {{cite journal | vauthors = Hefner Y, Borsch-Haubold AG, Murakami M, Wilde JI, Pasquet S, Schieltz D, Ghomashchi F, Yates J, Armstrong CG, Paterson A, Cohen P, Fukunaga R, Hunter T, Kudo I, Watson SP, Gelb MH | title = Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases | journal = Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37542–37551 | date = Dec 2000 | pmid = 10978317 | doi = 10.1074/jbc.M003395200 | doi-access = free }}
  • {{cite journal | vauthors = Arthur JS, Cohen P | title = MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells | journal = FEBS Letters | volume = 482 | issue = 1–2 | pages = 44–48 | date = Sep 2000 | pmid = 11018520 | doi = 10.1016/S0014-5793(00)02031-7 | doi-access = free }}
  • {{cite journal | vauthors = Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR | title = Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth | journal = Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19469–19482 | date = Jun 2001 | pmid = 11297520 | doi = 10.1074/jbc.M009953200 | doi-access = free }}
  • {{cite journal | vauthors = Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR | title = Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3 | journal = The EMBO Journal | volume = 20 | issue = 10 | pages = 2487–2496 | date = May 2001 | pmid = 11350938 | pmc = 125453 | doi = 10.1093/emboj/20.10.2487 }}
  • {{cite journal | vauthors = Liu G, Zhang Y, Bode AM, Ma WY, Dong Z | title = Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation | journal = Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 8810–8816 | date = Mar 2002 | pmid = 11777913 | doi = 10.1074/jbc.M110477200 | doi-access = free }}
  • {{cite journal | vauthors = Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS | title = MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2871–2881 | date = Apr 2002 | pmid = 11909979 | pmc = 133730 | doi = 10.1128/MCB.22.8.2871-2881.2002 }}
  • {{cite journal | vauthors = Markou T, Lazou A | title = Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase | journal = The Biochemical Journal | volume = 365 | issue = Pt 3 | pages = 757–763 | date = Aug 2002 | pmid = 11994045 | pmc = 1222733 | doi = 10.1042/BJ20011828 }}
  • {{cite journal | vauthors = Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J | title = Regulation of tyrosine hydroxylase by stress-activated protein kinases | journal = Journal of Neurochemistry | volume = 83 | issue = 4 | pages = 775–783 | date = Nov 2002 | pmid = 12421349 | doi = 10.1046/j.1471-4159.2002.01172.x | doi-access = free }}
  • {{cite journal | vauthors = Janknecht R | title = Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1) | journal = Oncogene | volume = 22 | issue = 5 | pages = 746–755 | date = Feb 2003 | pmid = 12569367 | doi = 10.1038/sj.onc.1206185 | s2cid = 30183941 }}
  • {{cite journal | vauthors = Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL | title = Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis | journal = Clinical Cancer Research | volume = 9 | issue = 2 | pages = 594–600 | date = Feb 2003 | pmid = 12576423 }}

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{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

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