RRAD (gene)
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Ras Related Glycolysis Inhibitor and Calcium Channel Regulator (RRAD) is a protein that in humans is encoded by the RRAD gene.{{cite journal | vauthors = Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS | title = Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q | journal = Diabetes | volume = 44 | issue = 2 | pages = 243–7 | date = March 1995 | pmid = 7859947 | doi = 10.2337/diabetes.44.2.243 }}{{cite web | title = Entrez Gene: RRAD Ras-related associated with diabetes| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6236}} RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis.{{cite journal |last1=Zhang |first1=Cen |title=Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD |journal=Oncotarget |date=2014 |volume=4 |issue=14 |pages=5535–5546 |doi=10.18632/oncotarget.2137 |pmid=25114038 |pmc=4170611 }}
Interactions
RRAD has been shown to interact with CAMK2G{{cite journal | vauthors = Moyers JS, Bilan PJ, Zhu J, Kahn CR | title = Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 11832–9 | date = May 1997 | pmid = 9115241 | doi = 10.1074/jbc.272.18.11832 | doi-access = free }} and TPM2.{{cite journal | vauthors = Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR | title = Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin | journal = J. Biol. Chem. | volume = 271 | issue = 2 | pages = 768–73 | date = January 1996 | pmid = 8557685 | doi = 10.1074/jbc.271.2.768 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Zhu J, Reynet C, Caldwell JS, Kahn CR | title = Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity | journal = J. Biol. Chem. | volume = 270 | issue = 9 | pages = 4805–12 | year = 1995 | pmid = 7876254 | doi = 10.1074/jbc.270.9.4805 | doi-access = free }}
- {{cite journal | vauthors = Reynet C, Kahn CR | title = Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans | journal = Science | volume = 262 | issue = 5138 | pages = 1441–4 | year = 1993 | pmid = 8248782 | doi = 10.1126/science.8248782 | bibcode = 1993Sci...262.1441R }}
- {{cite journal | vauthors = Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR | title = Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin | journal = J. Biol. Chem. | volume = 271 | issue = 2 | pages = 768–73 | year = 1996 | pmid = 8557685 | doi = 10.1074/jbc.271.2.768 | doi-access = free }}
- {{cite journal | vauthors = Caldwell JS, Moyers JS, Doria A, Reynet C, Kahn RC | title = Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence | journal = Biochim. Biophys. Acta | volume = 1316 | issue = 3 | pages = 145–8 | year = 1996 | pmid = 8781531 | doi = 10.1016/0925-4439(96)00034-8 | doi-access = free }}
- {{cite journal | vauthors = Moyers JS, Bilan PJ, Reynet C, Kahn CR | title = Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells | journal = J. Biol. Chem. | volume = 271 | issue = 38 | pages = 23111–6 | year = 1996 | pmid = 8798502 | doi = 10.1074/jbc.271.38.23111 | doi-access = free }}
- {{cite journal | vauthors = Moyers JS, Bilan PJ, Zhu J, Kahn CR | title = Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 11832–9 | year = 1997 | pmid = 9115241 | doi = 10.1074/jbc.272.18.11832 | doi-access = free }}
- {{cite journal | vauthors = Moyers JS, Zhu J, Kahn CR | title = Effects of phosphorylation on function of the Rad GTPase | journal = Biochem. J. | volume = 333 ( Pt 3) | issue = 3 | pages = 609–14 | year = 1998 | pmid = 9677319 | pmc = 1219623 | doi = 10.1042/bj3330609}}
- {{cite journal | vauthors = Finlin BS, Andres DA | title = Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins | journal = Arch. Biochem. Biophys. | volume = 368 | issue = 2 | pages = 401–12 | year = 1999 | pmid = 10441394 | doi = 10.1006/abbi.1999.1316 }}
- {{cite journal | vauthors = Zhu J, Tseng YH, Kantor JD, Rhodes CJ, Zetter BR, Moyers JS, Kahn CR | title = Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 26 | pages = 14911–8 | year = 1999 | pmid = 10611312 | pmc = 24747 | doi = 10.1073/pnas.96.26.14911 | bibcode = 1999PNAS...9614911Z | doi-access = free }}
- {{cite journal | vauthors = Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR | title = Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23 | journal = Cancer Res. | volume = 61 | issue = 5 | pages = 2071–9 | year = 2001 | pmid = 11280768 }}
- {{cite journal | vauthors = Yanuar A, Sakurai S, Kitano K, Hakoshima T | title = Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase | journal = Acta Crystallographica Section F | volume = 61 | issue = Pt 11 | pages = 978–80 | year = 2005 | pmid = 16511212 | pmc = 1978125 | doi = 10.1107/S1744309105031982 }}
- {{cite journal | vauthors = Yanuar A, Sakurai S, Kitano K, Hakoshima T | title = Crystal structure of human Rad GTPase of the RGK-family | journal = Genes Cells | volume = 11 | issue = 8 | pages = 961–8 | year = 2006 | pmid = 16866878 | doi = 10.1111/j.1365-2443.2006.00994.x | s2cid = 23729185 | doi-access = free }}
- {{cite journal | vauthors = Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Minna JD, Fujisawa T, Gazdar AF | title = Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers | journal = Ann. Surg. Oncol. | volume = 14 | issue = 4 | pages = 1397–404 | year = 2007 | pmid = 17195088 | doi = 10.1245/s10434-006-9089-6 | s2cid = 24884607 }}
- {{cite journal | vauthors = Yada H, Murata M, Shimoda K, Yuasa S, Kawaguchi H, Ieda M, Adachi T, Murata M, Ogawa S, Fukuda K | title = Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart | journal = Circ. Res. | volume = 101 | issue = 1 | pages = 69–77 | year = 2007 | pmid = 17525370 | doi = 10.1161/CIRCRESAHA.106.146399 | doi-access = free }}
- {{cite journal | vauthors = Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M | title = Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns | journal = Genome Biol. | volume = 8 | issue = 8 | pages = R154 | year = 2007 | pmid = 17672918 | pmc = 2374985 | doi = 10.1186/gb-2007-8-8-r154 | doi-access = free }}
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External links
- {{PDBe-KB2|P55042|Human GTP-binding protein RAD (RRAD)}}
{{PDB Gallery|geneid=6236}}
{{gene-16-stub}}