RREB1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.{{cite journal |vauthors=Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD | title = RREB1, a ras responsive element binding protein, maps to human chromosome 6p25 | journal = Genomics | volume = 45 | issue = 3 | pages = 630–632 |date=Jan 1998 | pmid = 9367691 | doi = 10.1006/geno.1997.5001 | doi-access = free }}{{cite journal |vauthors=Melani M, Simpson KJ, Brugge JS, Montell D | title = Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1 | journal = Curr Biol | volume = 18 | issue = 7 | pages = 532–537 |date=Apr 2008 | pmid = 18394891 | doi = 10.1016/j.cub.2008.03.024 | s2cid = 17251337 | doi-access = free | bibcode = 2008CBio...18..532M }}{{cite web | title = Entrez Gene: RREB1 ras responsive element binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6239}}
Clinical significance
Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.{{Cite journal
| pmid = 25027322
| year = 2014
| last1 = Bonomo
| first1 = J. A.
| title = The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease
| journal = Human Molecular Genetics
| last2 = Guan
| first2 = M
| last3 = Ng
| first3 = M. C.
| last4 = Palmer
| first4 = N. D.
| last5 = Hicks
| first5 = P. J.
| last6 = Keaton
| first6 = J. M.
| last7 = Lea
| first7 = J. P.
| last8 = Langefeld
| first8 = C. D.
| last9 = Freedman
| first9 = B. I.
| last10 = Bowden
| first10 = D. W.
| doi = 10.1093/hmg/ddu362
| volume=23
| issue = 24
| pages=6441–7
| pmc=4240197
}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | author=Thiagalingam A |title=RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5335–45 |year= 1996 |pmid= 8816445 |doi= 10.1128/mcb.16.10.5335| pmc=231532 | author2=De Bustros A | author3=Borges M | last4=Jasti | first4=R | last5=Compton | first5=D | last6=Diamond | first6=L | last7=Mabry | first7=M | last8=Ball | first8=DW | last9=Baylin | first9=SB }}
- {{cite journal | author=Fujimoto-Nishiyama A |title=A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies |journal=Gene |volume=195 |issue= 2 |pages= 267–275 |year= 1997 |pmid= 9305772 |doi=10.1016/S0378-1119(97)00172-8 | author2=Ishii S | author3=Matsuda S | last4=Inoue | first4=Jun-Ichiro | last5=Yamamoto | first5=Tadashi }}
- {{cite journal |vauthors=Zhang L, Zhao J, Edenberg HJ |title=A human Raf-responsive zinc-finger protein that binds to divergent sequences |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2947–2956 |year= 1999 |pmid= 10390538 |doi=10.1093/nar/27.14.2947 | pmc=148511 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD | bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Ray SK |title=Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1 |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 259–271 |year= 2003 |pmid= 12482979 |doi=10.1128/MCB.23.1.259-271.2003 | pmc=140679 | author2=Nishitani J | author3=Petry MW | last4=Fessing | first4=M. Y. | last5=Leiter | first5=A. B. }}
- {{cite journal | author=Zhang S |title=p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB |journal=Oncogene |volume=22 |issue= 15 |pages= 2285–2295 |year= 2003 |pmid= 12700664 |doi= 10.1038/sj.onc.1206257 | author2=Qian X | author3=Redman C | last4=Bliskovski | first4=Valeri | last5=Ramsay | first5=Edward S | last6=Lowy | first6=Douglas R | last7=Mock | first7=Beverly A | doi-access= |s2cid=917155 }}
- {{cite journal | author=Shi Y |title=Coordinated histone modifications mediated by a CtBP co-repressor complex |journal=Nature |volume=422 |issue= 6933 |pages= 735–738 |year= 2003 |pmid= 12700765 |doi= 10.1038/nature01550 | author2=Sawada J | author3=Sui G | last4=Affar | first4=El Bachir | last5=Whetstine | first5=Johnathan R. | last6=Lan | first6=Fei | last7=Ogawa | first7=Hidesato | last8=Po-Shan Luke | first8=Margaret | last9=Nakatani | first9=Yoshihiro |bibcode=2003Natur.422..735S |s2cid=2670859 }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y | author3=Nishikawa T | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Date S |title=Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene |journal=Int. J. Mol. Med. |volume=13 |issue= 5 |pages= 637–42 |year= 2005 |pmid= 15067362 |doi= 10.3892/ijmm.13.5.637| author2=Nibu Y | author3=Yanai K | last4=Hirata | first4=J | last5=Yagami | first5=K | last6=Fukamizu | first6=A }}
- {{cite journal | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–12135 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 | author2=Jedrychowski M | author3=Schwartz D | last4=Elias | first4=JE | last5=Villén | first5=J | last6=Li | first6=J | last7=Cohn | first7=MA | last8=Cantley | first8=LC | last9=Gygi | first9=SP |bibcode=2004PNAS..10112130B |doi-access=free }}
{{refend}}
{{gene-6-stub}}