RTL3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Retrotransposon Gag like 3 is a protein that in humans is encoded by the RTL3 gene.

{{cite web

| title = Entrez Gene: Retrotransposon Gag like 3

| url = https://www.ncbi.nlm.nih.gov/gene/203430

| access-date = 2017-09-18

}}

Function

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. Retrotransposon gag-like-3 (RTL3/ZCCHC5/MART3) is one of eleven Sushi-like neogenes identified in the human genome7 RTL3 encodes a 53 kDa protein with a nucleic acid-binding domain (CX2CX4HX4C), gag-like region within the open reading frame and an ssDNA/RNA-binding homeobox-associated leucine zipper motif.{{cite journal | vauthors = Ball HC, Ansari MY, Ahmad N, Novak K, Haqqi TM | title = A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes | journal = Connective Tissue Research | volume = 62 | issue = 6 | pages = 615–628 | date = November 2021 | pmid = 33043724 | pmc = 8404968 | doi = 10.1080/03008207.2020.1828380 }} It has been reported that RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes.

RTL3

Function

References