RTN2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.{{cite journal |vauthors=Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK | title = Detailed comparative map of human chromosome 19q and related regions of the mouse genome | journal = Genomics | volume = 35 | issue = 3 | pages = 499–508 |date=Dec 1996 | pmid = 8812484 | doi = 10.1006/geno.1996.0390 | url = https://zenodo.org/record/1229687 }}{{cite journal |vauthors=Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML | title = Molecular cloning of a novel mouse gene with predominant muscle and neural expression | journal = Mamm Genome | volume = 9 | issue = 4 | pages = 274–82 |date=May 1998 | pmid = 9530622 | doi =10.1007/s003359900748 | s2cid = 7091637 }}{{cite web | title = Entrez Gene: RTN2 reticulon 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6253}}
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
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Further reading
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- {{cite journal | author=Ballif BA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |name-list-style=vanc| author2=Villén J | author3=Beausoleil SA | display-authors=3 | last4=Schwartz | first4=D | last5=Gygi | first5=SP |doi-access=free }}
- {{cite journal | author=He W |title=Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation |journal=Nat. Med. |volume=10 |issue= 9 |pages= 959–65 |year= 2004 |pmid= 15286784 |doi= 10.1038/nm1088 |name-list-style=vanc| author2=Lu Y | author3=Qahwash I | display-authors=3 | last4=Hu | first4=Xiang-You | last5=Chang | first5=Ansi | last6=Yan | first6=Riqiang |s2cid=23570406 }}
- {{cite journal | author=Reuter TY |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=10.1016/S0014-4827(03)00261-1 |name-list-style=vanc| author2=Medhurst AL | author3=Waisfisz Q | display-authors=3 | last4=Zhi | first4=Yu | last5=Herterich | first5=Sabine | last6=Hoehn | first6=Holger | last7=Gross | first7=Hans J | last8=Joenje | first8=Hans | last9=Hoatlin | first9=Maureen E }}
- {{cite journal |vauthors=Oertle T, Klinger M, Stuermer CA, Schwab ME |title=A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family |journal=FASEB J. |volume=17 |issue= 10 |pages= 1238–47 |year= 2003 |pmid= 12832288 |doi= 10.1096/fj.02-1166hyp |doi-access=free |s2cid=27903 |url=http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-39197 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML |title=Nspl1, a new Z-band-associated protein |journal=J. Muscle Res. Cell. Motil. |volume=20 |issue= 7 |pages= 661–8 |year= 2000 |pmid= 10672514 |doi=10.1023/A:1005533013926 |s2cid=26327921 }}
- {{cite journal |vauthors=Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ |title=cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons |journal=Genomics |volume=51 |issue= 1 |pages= 98–106 |year= 1998 |pmid= 9693037 |doi= 10.1006/geno.1997.5175 }}
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{{gene-19-stub}}