Randy Read
{{short description|Canadian-British scientist (1957–)}}
{{EngvarB|date=August 2017}}
{{Use dmy dates|date=August 2017}}
{{Infobox scientist
| name = Randy Read
| honorific_suffix = {{post-nominals|country=GBR|FRS|size=100%}}
| birth_name = Randy John Read
| image = Professor_Randy_Read_FRS.jpg
| image_size =
| alt =
| caption = Randy Read at the Royal Society admissions day in London, July 2014
| birth_date = {{Birth date and age|df=yes|1957|06|09}}
| birth_place =
| other_names =
| residence =
| citizenship =
| nationality =
| fields = {{Plainlist|
| workplaces = University of Cambridge
| patrons =
| alma_mater = University of Alberta (BSc, PhD)
| thesis_title = X-ray crystallographic studies on serine proteinases and their protein inhibitors
| thesis_url = http://hdl.handle.net/10402/era.3098
| thesis_year = 1986
| academic_advisors =
| doctoral_students =
| notable_students =
| known_for = {{Plainlist|
- Phaser
- PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography){{Cite journal | doi = 10.1107/S0907444902016657| pmid = 12393927| title = PHENIX: Building new software for automated crystallographic structure determination| journal = Acta Crystallographica Section D| volume = 58| issue = 11| pages = 1948–1954| year = 2002| last1 = Adams | first1 = P. D. | last2 = Grosse-Kunstleve | first2 = R. W. | last3 = Hung | first3 = L. W. | last4 = Ioerger | first4 = T. R. | last5 = McCoy | first5 = A. J. | last6 = Moriarty | first6 = N. W. | last7 = Read | first7 = R. J. | last8 = Sacchettini | first8 = J. C. | last9 = Sauter | first9 = N. K. | last10 = Terwilliger | first10 = T. C. | doi-access = free | bibcode = 2002AcCrD..58.1948A| hdl = 1969.1/180215 | hdl-access = free }}}}{{Cite journal |last1=Liebschner |first1=Dorothee |last2=Afonine |first2=Pavel V. |last3=Baker |first3=Matthew L. |last4=Bunkóczi |first4=Gábor |last5=Chen |first5=Vincent B. |last6=Croll |first6=Tristan I. |last7=Hintze |first7=Bradley |last8=Hung |first8=Li-Wei |last9=Jain |first9=Swati |last10=McCoy |first10=Airlie J. |last11=Moriarty |first11=Nigel W. |last12=Oeffner |first12=Robert D. |last13=Poon |first13=Billy K. |last14=Prisant |first14=Michael G. |last15=Read |first15=Randy J. |date=2019-10-01 |title=Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix |url=https://scripts.iucr.org/cgi-bin/paper?S2059798319011471 |journal=Acta Crystallographica Section D: Structural Biology |volume=75 |issue=10 |pages=861–877 |doi=10.1107/S2059798319011471 |issn=2059-7983 |pmc=6778852 |pmid=31588918|bibcode=2019AcCrD..75..861L }}
| doctoral_advisor = Michael N. G. James{{cite journal|last1=Fujinaga|first1=Masao|last2=Sielecki|first2=Anita R.|last3=Read|first3=Randy J.|last4=Ardelt|first4=Wojciech|last5=Laskowski|first5=Michael|last6=James|first6=Michael N.G.|title=Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor Turkey ovomucoid third domain at 1.8 Å resolution|journal=Journal of Molecular Biology|volume=195|issue=2|year=1987|pages=397–418|issn=0022-2836|doi=10.1016/0022-2836(87)90659-0|pmid= 3477645}}
| influences =
| influenced =
| awards = Wellcome Trust Principal Research Fellow
| website = {{URL|https://www.cimr.cam.ac.uk/staff/professor-randy-j-read-frs
}}
| footnotes =
| spouse =
| children =
}}
Randy John Read {{post-nominals|country=GBR|FRS}}{{cite web |url=http://royalsociety.org/people/fellowship/2014/randy-read/ |title = Professor Randy Read FRS |publisher=royalsociety.org |author=Anon|year=2014|archivedate=2014-08-05|archiveurl=https://web.archive.org/web/20140805043415/https://royalsociety.org/people/fellowship/2014/randy-read/ |location=London}} (born 9 June 1957){{Who's Who | title=Read, Prof. Randy John | id = U43034 | year = 2014 | edition = online Oxford University Press|author=Anon|doi=10.1093/ww/9780199540884.013.43034}} is a Wellcome Trust Principal Research Fellow and professor of protein crystallography at the University of Cambridge.{{Google scholar id}}{{Scopus id}}{{cite web|archiveurl=https://web.archive.org/web/20130515145812/http://www-structmed.cimr.cam.ac.uk/Personal/randy/|archivedate=2013-05-15|url=http://www.cimr.cam.ac.uk/research/principal-investigators/principal-investigators-q-z/read|title=Randy Read's Homepage|publisher=University of Cambridge|first=Randy|last=Read|year=2017}} {{dead|date=July 2017}}{{EuropePMC|ORCID=0000-0001-8273-0047}}
Education
Read was educated at the University of Alberta in Edmonton, Canada where he was awarded a Bachelor of Science degree in 1979 followed by a PhD in 1986 for X-ray crystallography of serine proteases and their protein inhibitors supervised by Michael N. G. James.{{cite thesis |degree=PhD |first=Randy John|last=Read |title=X-ray crystallographic studies on serine proteinases and their protein inhibitors|year=1986 |authorlink=Randy Read|doi=10.7939/R33776175|hdl=10402/era.3098|id={{ProQuest|250072156}}}}
Career and research
Following his PhD, Read was appointed assistant professor from 1988 to 1993 and associate professor from 1993 to 1998 at the University of Alberta. {{As of|2017}}, Read's research interests are in protein crystallography and maximum likelihood estimation. His research has been published in leading peer reviewed scientific journals including Nature,{{Cite journal | doi = 10.1038/nature09505| pmid = 20927107| pmc = 3024006| title = A redox switch in angiotensinogen modulates angiotensin release| journal = Nature| volume = 468| issue = 7320| pages = 108–11| year = 2010| last1 = Zhou | first1 = A. | last2 = Carrell | first2 = R. W. | last3 = Murphy | first3 = M. P. | last4 = Wei | first4 = Z. | last5 = Yan | first5 = Y. | last6 = Stanley | first6 = P. L. D. | last7 = Stein | first7 = P. E. | last8 = Pipkin | first8 = F. B. | last9 = Read | first9 = R. J.
| bibcode = 2010Natur.468..108Z}}{{Cite journal | doi = 10.1038/nature09964| pmid = 21532589| title = Improved molecular replacement by density- and energy-guided protein structure optimization| journal = Nature| volume = 473| issue = 7348| pages = 540–3| year = 2011| last1 = Dimaio | first1 = F. | last2 = Terwilliger | first2 = T. C. | last3 = Read | first3 = R. J. | authorlink3 = Randy Read| last4 = Wlodawer | first4 = A. | last5 = Oberdorfer | first5 = G. | last6 = Wagner | first6 = U. | last7 = Valkov | first7 = E. | last8 = Alon | first8 = A. | last9 = Fass | first9 = D. | last10 = Axelrod | first10 = H. L. | last11 = Das | first11 = D. | last12 = Vorobiev | first12 = S. M. | last13 = Iwaï | first13 = H. | last14 = Pokkuluri | first14 = P. R. | last15 = Baker | first15 = D. | authorlink15 = David Baker (biochemist) | pmc=3365536| bibcode = 2011Natur.473..540D}}{{Cite journal | doi = 10.1038/nature06249| pmid = 17934447| title = High-resolution structure prediction and the crystallographic phase problem| journal = Nature| volume = 450| issue = 7167| pages = 259–64| year = 2007| last1 = Qian | first1 = B. | last2 = Raman | first2 = S. | last3 = Das | first3 = R. | last4 = Bradley | first4 = P. | last5 = McCoy | first5 = A. J. | last6 = Read | first6 = R. J. | authorlink6 = Randy Read| last7 = Baker | first7 = D. | authorlink7 = David Baker (biochemist) | pmc=2504711| bibcode = 2007Natur.450..259Q}} Science,{{Cite journal
| pmid = 25103409
| pmc = 4188430
| year = 2014
| last1 = Jackson
| first1 = R. N.
| title = Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli
| journal = Science
| volume = 345
| issue = 6203
| pages = 1473–9
| last2 = Golden
| first2 = S. M.
| last3 = Van Erp
| first3 = P. B.
| last4 = Carter
| first4 = J
| last5 = Westra
| first5 = E. R.
| last6 = Brouns
| first6 = S. J.
| last7 = Van Der Oost
| first7 = J
| last8 = Terwilliger
| first8 = T. C.
| last9 = Read
| first9 = R. J.
| last10 = Wiedenheft
| first10 = B
| doi = 10.1126/science.1256328
}} the Journal of Applied Crystallography{{Cite journal | doi = 10.1107/S0021889807021206| pmid = 19461840| title = Phaser crystallographic software| journal = Journal of Applied Crystallography| volume = 40| issue = 4| pages = 658–674| year = 2007| last1 = McCoy | first1 = A. J. | last2 = Grosse-Kunstleve | first2 = R. W. | last3 = Adams | first3 = P. D. | last4 = Winn | first4 = M. D. | last5 = Storoni | first5 = L. C. | last6 = Read | first6 = R. J. | pmc = 2483472| bibcode = 2007JApCr..40..658M| authorlink6 = Randy Read| citeseerx = 10.1.1.322.8550}} Acta Crystallographica,{{Cite journal | doi = 10.1107/S0907444909052925| title = PHENIX: A comprehensive Python-based system for macromolecular structure solution| journal = Acta Crystallographica Section D| volume = 66| issue = 2| pages = 213–21| year = 2010| last1 = Adams | first1 = P. D. | last2 = Afonine | first2 = P. V. | last3 = Bunkóczi | first3 = G. B. | last4 = Chen | first4 = V. B. | last5 = Davis | first5 = I. W. | last6 = Echols | first6 = N. | last7 = Headd | first7 = J. J. | last8 = Hung | first8 = L. W. | last9 = Kapral | first9 = G. J. | last10 = Grosse-Kunstleve | first10 = R. W. | last11 = McCoy | first11 = A. J. | last12 = Moriarty | first12 = N. W. | last13 = Oeffner | first13 = R. | last14 = Read | first14 = R. J. | last15 = Richardson | first15 = D. C. | last16 = Richardson | first16 = J. S. | last17 = Terwilliger | first17 = T. C. | last18 = Zwart | first18 = P. H. | pmid=20124702 | pmc=2815670| bibcode = 2010AcCrD..66..213A}}{{Cite journal | doi = 10.1107/S0907444998003254| title = Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination| journal = Acta Crystallographica Section D| volume = 54| issue = 5| pages = 905–21| year = 1998| last1 = Brünger | first1 = A. T.| last2 = Adams | first2 = P. D.| last3 = Clore | first3 = G. M.| last4 = Delano | first4 = W. L.| last5 = Gros | first5 = P.| last6 = Grosse-Kunstleve | first6 = R. W.| last7 = Jiang | first7 = J. S.| last8 = Kuszewski | first8 = J.| last9 = Nilges | first9 = M.| last10 = Pannu | first10 = N. S.| last11 = Read | first11 = R. J.| last12 = Rice | first12 = L. M.| last13 = Simonson | first13 = T.| last14 = Warren | first14 = G. L. | pmid=9757107| bibcode = 1998AcCrD..54..905B| s2cid = 33910776}}{{Cite journal
| pmid = 19171969
| pmc = 2631636
| year = 2009
| last1 = Read
| first1 = R. J. | authorlink1 = Randy Read
| title = Case-controlled structure validation
| journal = Acta Crystallographica Section D
| volume = 65
| issue = Pt 2
| pages = 140–7
| last2 = Kleywegt
| first2 = G. J. | authorlink2 = Gerard Kleywegt
| doi = 10.1107/S0907444908041085
| bibcode = 2009AcCrD..65..140R
| pmid = 22000512
| pmc = 3195755
| year = 2011
| last1 = Read
| first1 = R. J.
| title = A new generation of crystallographic validation tools for the protein data bank
| journal = Structure
| volume = 19
| issue = 10
| pages = 1395–412
| last2 = Adams
| first2 = P. D.
| last3 = Arendall Wb
| first3 = 3rd
| last4 = Brunger
| first4 = A. T.
| last5 = Emsley
| first5 = P
| last6 = Joosten
| first6 = R. P.
| last7 = Kleywegt
| first7 = G. J.
| last8 = Krissinel
| first8 = E. B.
| last9 = Lütteke
| first9 = T
| last10 = Otwinowski
| first10 = Z
| last11 = Perrakis
| first11 = A
| last12 = Richardson
| first12 = J. S.
| last13 = Sheffler
| first13 = W. H.
| last14 = Smith
| first14 = J. L.
| last15 = Tickle
| first15 = I. J.
| last16 = Vriend
| first16 = G
| last17 = Zwart
| first17 = P. H.
| doi = 10.1016/j.str.2011.08.006
| pmid = 9438862
| year = 1997
| last1 = Kleywegt
| first1 = G. J. | authorlink1 = Gerard Kleywegt
| title = Not your average density
| journal = Structure
| volume = 5
| issue = 12
| pages = 1557–69
| last2 = Read
| first2 = R. J.| authorlink2 = Randy Read
| doi=10.1016/s0969-2126(97)00305-5
| doi-access = free
| pmid = 21876145
| pmc = 3174575
| year = 2011
| last1 = Deane
| first1 = J. E.
| title = Insights into Krabbe disease from structures of galactocerebrosidase
| journal = Proceedings of the National Academy of Sciences
| volume = 108
| issue = 37
| pages = 15169–73
| last2 = Graham
| first2 = S. C.
| last3 = Kim
| first3 = N. N.
| last4 = Stein
| first4 = P. E.
| last5 = McNair
| first5 = R
| last6 = Cachón-González
| first6 = M. B.
| last7 = Cox
| first7 = T. M.
| last8 = Read
| first8 = R. J.
| doi = 10.1073/pnas.1105639108
| doi-access = free
}} the Journal of Molecular Biology{{Cite journal
| pmid = 18513745
| year = 2008
| last1 = Zhou
| first1 = A
| title = The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release
| journal = Journal of Molecular Biology
| volume = 380
| issue = 1
| pages = 244–51
| last2 = Wei
| first2 = Z
| last3 = Stanley
| first3 = P. L.
| last4 = Read
| first4 = R. J.
| last5 = Stein
| first5 = P. E.
| last6 = Carrell
| first6 = R. W.
| doi = 10.1016/j.jmb.2008.05.012
| doi-access = free
}}{{Cite journal |last1=Stoop |first1=A. A. |last2=Eldering |first2=E |last3=Dafforn |first3=T. R. |last4=Read |first4=R. J. |last5=Pannekoek |first5=H |year=2001 |title=Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries |url=https://pubmed.ncbi.nlm.nih.gov/11162091/ |journal=Journal of Molecular Biology |volume=305 |issue=4 |pages=773–83 |doi=10.1006/jmbi.2000.4356 |pmid=11162091 |access-date=6 May 2022 |archive-date=6 May 2022 |archive-url=https://web.archive.org/web/20220506091632/https://pubmed.ncbi.nlm.nih.gov/11162091/ |url-status=live }} and the Journal of Clinical Endocrinology and Metabolism.{{Cite journal
| pmid = 23783094
| pmc = 3813945
| year = 2013
| last1 = Chan
| first1 = W. L.
| title = How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration
| journal = The Journal of Clinical Endocrinology & Metabolism
| volume = 98
| issue = 8
| pages = 3315–22
| last2 = Carrell
| first2 = R. W.
| last3 = Zhou
| first3 = A
| last4 = Read
| first4 = R. J.
| doi = 10.1210/jc.2012-4280
}}
=Awards and honours=
Read was elected Fellow of the Royal Society (FRS) in 2014. His nomination reads: {{centred pull quote|Professor Read is known internationally for his outstanding and fundamental contributions to the development of macromolecular crystallographic software. His application of maximum likelihood based algorithms to the solution of macromolecular crystal structures by molecular replacement (a technique that uses a known structure of a homologue to solve an unknown structure) has resulted in software (Phaser) that is foremost in the field. He also devised and demonstrated an improved likelihood target function for model refinement that has been adopted by all major refinement programs. In addition, Professor Read has led structural work that has made significant contributions to understanding the mechanisms of proteins relevant to disease (bacterial toxins and serpins).}}
References
{{reflist}}
{{FRS 2014}}
{{Authority control}}
{{DEFAULTSORT:Read, Randy John}}
Category:Canadian crystallographers
Category:Fellows of the Royal Society
Category:University of Alberta alumni
Category:British crystallographers
Category:Academic staff of the University of Alberta