Receptor tyrosine kinase-like orphan receptor

{{Infobox protein family

| Symbol = ROR

| Name = Receptor tyrosine kinase-like orphan receptor

| image =

| width =

| caption =

| Pfam=

| InterPro= IPR016247

| SMART=

| Prosite =

| SCOP =

| TCDB =

| OPM family=

| OPM protein=

| PDB=

| Membranome family = 720

}}

{{infobox protein

| Name = receptor tyrosine kinase-like orphan receptor 1

| caption =

| image =

| width =

| HGNCid = 10256

| Symbol = ROR1

| AltSymbols = NTRKR1

| EntrezGene = 4919

| OMIM = 602336

| RefSeq = NM_005012

| UniProt = Q01973

| PDB =

| ECnumber = 2.7.10.1

| Chromosome = 1

| Arm = p

| Band = 32

| LocusSupplementaryData = -p31

}}

{{infobox protein

| Name = receptor tyrosine kinase-like orphan receptor 2

| caption =

| image =

| width =

| HGNCid = 10257

| Symbol = ROR2

| AltSymbols = NTRKR2, BDB, BDB1

| EntrezGene = 4920

| OMIM = 602337

| RefSeq = NM_004560

| UniProt = Q01974

| PDB =

| ECnumber =

| Chromosome = 9

| Arm = q

| Band = 22

| LocusSupplementaryData =

}}

In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. ROR proteins (ROR1 and ROR2 in humans) can modulate Wnt signaling by sequestering Wnt ligands.{{cite journal |vauthors=Green JL, Kuntz SG, Sternberg PW | title = Ror receptor tyrosine kinases: orphans no more | journal = Trends Cell Biol. | volume = 18 | issue = 11 | pages = 536–44 |date=November 2008 | pmid = 18848778 | doi = 10.1016/j.tcb.2008.08.006 | pmc = 4672995 }}