Related to receptor tyrosine kinase

The gene encoding mouse RYK was first identified in 1992.{{cite journal|vauthors=Hovens CM, Stacker SA|title=RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs|journal=Proc. Natl. Acad. Sci. USA|year=1992|volume=89|issue=24|pages=11818–11822|pmid= 1334548|doi =10.1073/pnas.89.24.11818|pmc= 50648|bibcode=1992PNAS...8911818H |doi-access=free}}

Subsequently, cDNA encoding the RYK protein have been isolated from the following species.{{cite journal|vauthors=Halford MM, Stacker SA|title=Revelations of the RYK receptor|journal =BioEssays|year=2001|volume=23|issue=1|pages=34–45|pmid= 11135307|doi =10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D|s2cid=18535933 }}

• rat
• chicken
• Human
• Zebrafish
• Caenorhabditis elegans
• Drosophila

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.

RYK is involved in regulation of axon growth during development of the nervous system.{{cite journal|vauthors=Hollis ER, Ishiko N, Yu T, Lu CC, Haimovich A, Tolentino K, Richman A, Tury A, Wang SH, Pessian M, Jo E, Kolodkin A, Zou Y|year=2016|title=Ryk controls remapping of motor cortex during functional recovery after spinal cord injury|journal=Nature Neuroscience|volume=19|issue=5|pages= 697–705|doi= 10.1038/nn.4282 |pmc=4847956|pmid=27065364}}

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• {{cite journal |vauthors=Partanen J, Mäkelä TP, Alitalo R, etal |title=Putative tyrosine kinases expressed in K-562 human leukemia cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8913–8917 |year= 1991 |pmid= 2247464 |doi=10.1073/pnas.87.22.8913 | pmc=55070 |doi-access=free }}
• {{cite journal |vauthors=Gough NM, Rakar S, Hovens CM, Wilks A |title=Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 255–6 |year= 1995 |pmid= 7613029 |doi=10.1007/BF00352411 |s2cid=2577241 }}
• {{cite journal |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–3410 |year= 1993 |pmid= 8247543 }}
• {{cite journal |vauthors=Stacker SA, Hovens CM, Vitali A, etal |title=Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). |journal=Oncogene |volume=8 |issue= 5 |pages= 1347–1356 |year= 1993 |pmid= 8386829 }}
• {{cite journal |vauthors=Tamagnone L, Partanen J, Armstrong E, etal |title=The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. |journal=Oncogene |volume=8 |issue= 7 |pages= 2009–2014 |year= 1993 |pmid= 8390040 }}
• {{cite journal |vauthors=Wang XC, Katso R, Butler R, etal |title=H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. |journal=Mol. Med. |volume=2 |issue= 2 |pages= 189–203 |year= 1996 |pmid= 8726462 |doi= 10.1007/BF03401616| pmc=2230112 }}
• {{cite journal |vauthors=Katso RM, Russell RB, Ganesan TS |title=Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6427–6440 |year= 1999 |pmid= 10454588 |doi= 10.1128/mcb.19.9.6427| pmc=84612 }}
• {{cite journal |vauthors=Trivier E, Ganesan TS |title=RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23037–43 |year= 2002 |pmid= 11956217 |doi= 10.1074/jbc.M202486200 |doi-access= free }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
• {{cite journal |vauthors=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97–108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019 |s2cid=18567677 |doi-access=free }}
• {{cite journal |vauthors=Watanabe A, Akita S, Tin NT, etal |title=A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. |journal=Cleft Palate Craniofac. J. |volume=43 |issue= 3 |pages= 310–6 |year= 2006 |pmid= 16681403 |doi= 10.1597/04-145.1 |s2cid=23152169 }}
• {{cite journal |vauthors=Szafranski K, Schindler S, Taudien S, etal |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= Genome Biology|volume=8 |issue= 8 |pages= R154 |year= 2007|pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154 | pmc=2374985 |doi-access=free }}

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Category:Genes on human chromosome 3

Category:Tyrosine kinase receptors