Relaxin receptor

{{Short description|InterPro Family}}

{{infobox protein

| Name = relaxin/insulin-like family peptide receptor 1

| caption =

| image =

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| HGNCid = 19718

| Symbol = RXFP1

| AltSymbols = LGR7

| EntrezGene = 59350

| OMIM = 606654

| RefSeq = NM_021634

| UniProt = Q9HBX9

| PDB =

| ECnumber =

| Chromosome = 4

| Arm = q

| Band = 31.3

| LocusSupplementaryData =

}}

{{infobox protein

| Name = relaxin/insulin-like family peptide receptor 2

| caption =

| image =

| width =

| HGNCid = 17318

| Symbol = RXFP2

| AltSymbols = LGR8, GREAT, GPR106, INSL3R

| EntrezGene = 122042

| OMIM = 606655

| RefSeq = NM_130806

| UniProt = Q8WXD0

| PDB =

| ECnumber =

| Chromosome = 13

| Arm = q

| Band = 12.3

| LocusSupplementaryData =

}}

{{infobox protein

| Name = relaxin/insulin-like family peptide receptor 3

| caption =

| image =

| width =

| HGNCid = 24883

| Symbol = RXFP3

| AltSymbols = RLN3R1, SALPR, GPCR135

| EntrezGene = 51289

| OMIM = 609445

| RefSeq = NM_016568

| UniProt = Q9NSD7

| PDB =

| ECnumber =

| Chromosome = 5

| Arm = p

| Band = 15.1

| LocusSupplementaryData = -p14

}}

{{infobox protein

| Name = relaxin/insulin-like family peptide receptor 4

| caption =

| image =

| width =

| HGNCid = 14666

| Symbol = RXFP4

| AltSymbols = GPR100, GPCR142, RLN3R2

| EntrezGene = 339403

| OMIM = 609043

| RefSeq = NM_181885

| UniProt = Q8TDU9

| PDB =

| ECnumber =

| Chromosome = 1

| Arm = q

| Band = 22

| LocusSupplementaryData =

}}

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.{{cite journal |vauthors=Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ | title = International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides | journal = Pharmacol. Rev. | volume = 58 | issue = 1 | pages = 7–31 | year = 2006 | pmid = 16507880 | doi = 10.1124/pr.58.1.9 | s2cid = 7466039 }}{{cite journal |vauthors=Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ | title = Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways | journal = Br. J. Pharmacol. | volume = 150 | issue = 6 | pages = 677–91 | year = 2007 | pmid = 17293890 | doi = 10.1038/sj.bjp.0707140 | pmc = 2013861 }}

Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

class="wikitable"
receptor/gene ! ligands ! activates ! inhibits
{{gene|RXFP1}} | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
{{gene|RXFP2}} | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase |
{{gene|RXFP3}} | relaxin 3 | Erk1/2 signaling | adenylate cyclase
{{gene|RXFP4}} | relaxin 3, insulin-like 3 | | adenylate cyclase