Replication error phenotype

{{Short description|Subgroup of tumors}}

{{Onesource|article|date=January 2021}}

The positive replication error phenotype (RER+) defines a subgroup of tumors that have been documented well in Hereditary nonpolyposis colorectal cancer (HNPCC). More recently, this phenotype also has been described in breast carcinoma and is a predictor of metastases.{{cite journal |last1=Chagpar |first1=Anees |last2=Magliocco |first2=Anthony |last3=Kerviche |first3=Annette |last4=Tan |first4=Leonard |last5=Walley |first5=Barbara |last6=DeCoteau |first6=John F. |title=The replication error phenotype is associated with the development of distant metastases in hormonally treated patients with breast carcinoma |journal=Cancer |date=1 March 2004 |volume=100 |issue=5 |pages=913–919 |id={{INIST|15484040}} |doi=10.1002/cncr.20084 |pmid=14983485 |s2cid=25814306 }}