Replication timing quantitative trait loci

Replication timing quantitative trait loci (or rtQTL) are genetic variations that lead to differential use of replication origins, exhibiting allele-specific effects on replication timing.{{cite journal|last=Koren|first=Amnon|author2=Polak Paz |author3=Nemesh James |author4=Michaelson Jacob J |author5=Sebat Jonathan |author6=Sunyaev Shamil R |author7=McCarroll Steven A |date=Dec 2012|title=Differential relationship of DNA replication timing to different forms of human mutation and variation|journal=Am. J. Hum. Genet.|volume=91|issue=6|pages=1033–40|location = United States| pmid = 23176822|doi = 10.1016/j.ajhg.2012.10.018 |pmc=3516607}} Originally, 16 rtQTL were identified in an analysis of human genomes.{{Cite journal |pmid = 25416942|pmc = 4359889|year = 2014|last1 = Koren|first1 = A.|title = Genetic variation in human DNA replication timing|journal = Cell|volume = 159|issue = 5|pages = 1015–1026|last2 = Handsaker|first2 = R. E.|last3 = Kamitaki|first3 = N.|last4 = Karlić|first4 = R.|last5 = Ghosh|first5 = S.|last6 = Polak|first6 = P.|last7 = Eggan|first7 = K.|last8 = McCarroll|first8 = S. A.|doi = 10.1016/j.cell.2014.10.025}}