Reticulate acropigmentation of Kitamura
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| field = Dermatology
| symptoms = Coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern
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| onset = Teenagers and early adulthood
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| differential = Dowling–Degos disease
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Reticulate acropigmentation of Kitamura is a type of pigmentation disorder of the skin.{{cite book |last1=James |first1=William D. |last2=Elston |first2=Dirk |last3=Treat |first3=James R. |last4=Rosenbach |first4=Misha A. |last5=Neuhaus |first5=Isaac |title=Andrews' Diseases of the Skin: Clinical Dermatology |date=2020 |publisher=Elsevier |location=Edinburgh |isbn=978-0-323-54753-6 |page=867 |edition=13th |chapter-url=https://books.google.com/books?id=UEaEDwAAQBAJ&dq=Kitamura&pg=PA867 |language=en |chapter=36. Disturbances of pigmentation: Reticulate acropigmentation of Kitamura }} It presents with coloured freckle-like and slightly depressed flat spots arranged in a lace-like pattern on the backs of hands and feet. It tends to occur in skin folds of teenagers and in early adulthood, and darkens over time.
It is inherited in an autosomal-dominant fashion.
The condition is rare.{{cite web |title=Orphanet: Reticulate acropigmentation of Kitamura |url=https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=178307 |website=www.orpha.net |access-date=23 April 2019 |language=en}} It was first described in Japan, before recognising that is also occurs elsewhere.
Genetics
This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.{{citation needed|date=August 2022}}
See also
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External links
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| ICD10 = L81.8
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| OMIM = 615537
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| Orphanet = 178307
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Category:Disturbances of human pigmentation
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