Ribose-5-phosphate—ammonia ligase

{{infobox enzyme

| Name = Ribose-5-phosphate—ammonia ligase

| EC_number = 6.3.4.7

| CAS_number = 9082-52-4

| GO_code = 0050260

| image =

| width =

| caption =

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In enzymology, a ribose-5-phosphate—ammonia ligase ({{EnzExplorer|6.3.4.7}}) is an enzyme that catalyzes the chemical reaction

:ATP + ribose 5-phosphate + NH₃ $\backslash rightleftharpoons$ ADP + phosphate + 5-phosphoribosylamine

The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH₃, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). This enzyme participates in purine metabolism.