Rio Verde Grande

{{Infobox river

| name = Rio Verde Grande

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| pushpin_map = Brazil

| pushpin_map_caption= Mouth location in Brazil

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| source1_location = Minas Gerais

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| mouth_coordinates = {{coord|-14.561798|-43.876411|region:BR|format=dms|display=inline,title}}

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| subdivision_type1 = Country

| subdivision_name1 = Brazil

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Rio Verde Grande (Portuguese for "big green river") is a river of Minas Gerais state in eastern Brazil, that forms the boundary with Bahia state in its lowest reaches.

It is a tributary of the São Francisco River.

The Caminho dos Gerais State Park protects the sources of the Verde Pequeno River, a tributary of the Rio Verde Grande, which in turn is a tributary of the São Francisco River.{{sfn|Lucas|2007}}