Rozalyn Anderson
{{short description|Biochemist}}
{{Infobox scientist
| name = Rozalyn Anderson
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| workplaces = University of Wisconsin
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| alma_mater = Trinity College and University college, Dublin, Ireland
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| known_for = Caloric restriction longevity studies in primates
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| website = {{URL|https://andersonlab.medicine.wisc.edu/}}
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Rozalyn (Roz) Anderson is a professor at the University of Wisconsin School of Medicine and Public Health. She studies aging and caloric restriction in primates.{{cite web|url=http://aging.wisc.edu/research/affil.php?Ident=143|title=University of Wisconsin - Madison Institute on Aging, Madison, Wisconsin|publisher=aging.wisc.edu|accessdate=12 August 2014}}
Education
Anderson received her bachelor's degree from Trinity College, Dublin and her Ph.D. in biochemistry from University College Dublin. In 2000 she moved to Harvard Medical School, Boston, Massachusetts for a post-doctoral fellowship with David Sinclair, where she studied caloric restriction and aging in yeast. She began studying mammalian aging during a second post-doctoral fellowship with Richard Weindruch at the University of Wisconsin Institute on Aging and as an assistant scientist at the Wisconsin National Primate Research Center. She is currently a professor at the University of Wisconsin in the Department of Medicine in the Division of Geriatrics and Gerontology.{{Cite web|title={{!}} Department of Medicine|url=https://www.medicine.wisc.edu/people-search/people/staff/905/Anderson_Rozalyn|access-date=2022-02-13|website=www.medicine.wisc.edu}}{{cite web|url=http://www.medicine.wisc.edu/geriatrics/andersonlabmain|title=Rozalyn Anderson's Laboratory | University Of Wisconsin - Department of Medicine|publisher=medicine.wisc.edu|accessdate=12 August 2014}} Since 2014, Anderson has also been affiliated with the Division of Endocrinology, Diabetes and Metabolism.{{Cite web|title = Meet Our Faculty and Staff|url = https://www.medicine.wisc.edu/endocrinology/faculty|accessdate = 2015-09-12}}
Research
In the Sinclair laboratory at Harvard Medical School, Anderson researched the regulation of the lifespan by calorie restriction in yeast, demonstrating that lifespan could be extended by genetic manipulation of the NAD+ salvage pathway,{{Cite journal|title = Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels|journal = The Journal of Biological Chemistry|date = 2002-05-24|issn = 0021-9258|pmid = 11884393|pages = 18881–18890|volume = 277|issue = 21|doi = 10.1074/jbc.M111773200|first1 = Rozalyn M.|last1 = Anderson|first2 = Kevin J.|last2 = Bitterman|first3 = Jason G.|last3 = Wood|first4 = Oliver|last4 = Medvedik|first5 = Haim|last5 = Cohen|first6 = Stephen S.|last6 = Lin|first7 = Jill K.|last7 = Manchester|first8 = Jeffrey I.|last8 = Gordon|first9 = David A.|last9 = Sinclair|doi-access = free|pmc = 3745358}}{{Cite journal|title = Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae|journal = Nature|date = 2003-05-08|issn = 0028-0836|pmid = 12736687|pages = 181–185|volume = 423|issue = 6936|doi = 10.1038/nature01578|first1 = Rozalyn M.|last1 = Anderson|first2 = Kevin J.|last2 = Bitterman|first3 = Jason G.|last3 = Wood|first4 = Oliver|last4 = Medvedik|first5 = David A.|last5 = Sinclair|pmc=4802858| bibcode=2003Natur.423..181A }} and that calorie restriction downregulates NAD+.{{Cite journal|title = Yeast life-span extension by calorie restriction is independent of NAD fluctuation|journal = Science|date = 2003-12-19|issn = 1095-9203|pmid = 14605207|pages = 2124–2126|volume = 302|issue = 5653|doi = 10.1126/science.1088697|first1 = Rozalyn M.|last1 = Anderson|first2 = Magda|last2 = Latorre-Esteves|first3 = Ana Rute|last3 = Neves|first4 = Siva|last4 = Lavu|first5 = Oliver|last5 = Medvedik|first6 = Christopher|last6 = Taylor|first7 = Konrad T.|last7 = Howitz|first8 = Helena|last8 = Santos|first9 = David A.|last9 = Sinclair|pmc=4998187| bibcode=2003Sci...302.2124A }}
Anderson worked as part of the University of Wisconsin team that demonstrated that caloric restriction has a beneficial effect in rhesus monkeys, improves survival, and lowers the incidence of diseases including diabetes, cancer, and cardiovascular disease over the course of nearly three decades.{{cite journal | author = Colman RJ, Anderson RM, Johnson SC | title = Caloric restriction delays disease onset and mortality in rhesus monkeys | journal = Science | year = 2009| volume = 325| issue = 5937| pages = 201–4|bibcode = 2009Sci...325..201C |doi = 10.1126/science.1173635 | pmid=19590001 | pmc=2812811| last2 = Anderson | last3 = Johnson | last4 = Kastman | last5 = Kosmatka | last6 = Beasley | last7 = Allison | last8 = Cruzen | last9 = Simmons | last10 = Kemnitz | last11 = Weindruch | display-authors = 1 }}{{cite journal|author1=Colman RJ|author2=Beasley TM|author3=Kemnitz JW|author4=Johnson SC|author5=Weindruch R|author6=Anderson RM|title=Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys|journal=Nature Communications|date=Apr 1, 2014|volume=5|page=3557|doi=10.1038/ncomms4557|pmid=24691430|pmc=3988801|bibcode=2014NatCo...5.3557C}}{{cite journal |last1=Anderson |first1=R. M. |last2=Shanmuganayagam |first2=D. |last3=Weindruch |first3=R. |title=Caloric Restriction and Aging: Studies in Mice and Monkeys |journal=Toxicologic Pathology |volume=37 |issue=1 |pages=47–51 |year=2009 |pmid=19075044 |doi=10.1177/0192623308329476|pmc=3734859 }}{{cite journal |last1=Rezzi |first1=Serge |last2=Martin |first2=François-Pierre J. |last3=Shanmuganayagam |first3=Dhanansayan |last4=Colman |first4=Ricki J. |last5=Nicholson |first5=Jeremy K. |last6=Weindruch |first6=Richard |title=Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates |journal=Experimental Gerontology |volume=44 |issue=5 |pages=356–62 |year=2009 |pmid=19264119 |pmc=2822382 |doi=10.1016/j.exger.2009.02.008}} She continues to study caloric restriction, focusing on primate skeletal muscle, white adipose tissue, inflammation, mitochondrial dysfunction, and metabolic regulators of cancer growth.
In a 2014 interview discussing the different results of the National Institute of Aging and University of Wisconsin rhesus monkey caloric restriction studies, Anderson points out that due to the experimental setup, both the control and experimental groups were calorie restricted to some degree, which explains why no significant improvement was found in the experimental group. She also points out that the two studies are more informative due to their differing designs than if they had been performed identically.{{cite web|url=https://www.nytimes.com/2014/04/02/science/a-new-salvo-in-debate-over-caloric-restrictions-and-longevity.html|title=The New York Times|website=The New York Times |accessdate=12 August 2014}}
{{cite web|url=https://www.nytimes.com/2009/07/10/science/10aging.html?_r=1&|title=The New York Times|website=The New York Times |accessdate=12 August 2014}}
In 2013, Anderson won the Nathan Shock New Investigator Award from the Gerontological Society of America.{{Cite web|title = UWSMPH|url = http://www.med.wisc.edu/news-events/uw-geriatrics-scientist-wins-prestigious-nathan-shock-new-investigator-award/41526|website = UW School of Medicine and Public Health|accessdate = 2015-09-12|first = University of Wisconsin School of Medicine and Public|last = Health}}{{Cite web|title = Awardees - Nathan Shock Award|url = http://prod.geron.org/Membership/Awards/Awardees?start=8|archive-url = https://web.archive.org/web/20150721172752/http://prod.geron.org/Membership/Awards/Awardees?start=8|url-status = dead|archive-date = 2015-07-21|website = prod.geron.org|accessdate = 2015-09-12|first = Anthony|last = Rogers}}
From 2019-2021, Anderson served as the President of the American Aging Association.{{Cite web|title=Previous Meetings|url=https://www.americanagingassociation.org/previous-meetings|access-date=2022-02-13|website=www.americanagingassociation.org}}
Anderson is the co-editor-in-chief of The Journals of Gerontology Series A: Biological Sciences.{{Cite web|title = Oxford Journals {{!}} Medicine & Health & Science & Mathematics {{!}} The Journals of Gerontology: Series A {{!}} Editorial Board - Biological Sciences|url = http://www.oxfordjournals.org/our_journals/gerona/editorial_board1.html|archive-url = https://web.archive.org/web/20110609214840/http://www.oxfordjournals.org/our_journals/gerona/editorial_board1.html|url-status = dead|archive-date = 2011-06-09|website = www.oxfordjournals.org|accessdate = 2015-09-12}}
References
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External links
- [https://www.youtube.com/watch?v=FIHYv2mt8XY YouTube lecture]
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Category:Year of birth missing (living people)
Category:University of Wisconsin–Madison faculty
Category:Place of birth missing (living people)
Category:Alumni of Trinity College Dublin
Category:Alumni of University College Dublin
Category:American women biochemists