Rs1799913

{{Infobox single nucleotide polymorphism

| rsid = 1799913

| name_1 = A779C

| gene = TPH1

| chromosome = 11

| region = Intron 7

| szgene_geneid = 111

| szgene_polyid = 586

}}

In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene.

It is located in intron 7.{{Cite journal

| author = D. A. Nielsen, G. L. Jenkins, K. M. Stefanisko, K. K. Jefferson & D. Goldman

| title = Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7

| journal = Brain Research. Molecular Brain Research

| volume = 45

| issue = 1

| pages = 145–148

|date=April 1997

| pmid = 9105682

| doi = 10.1016/S0169-328X(96)00304-X

| url = https://zenodo.org/record/1259929

}}

The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion.{{Cite journal

| author = P. G. Sand

| title = Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia

| journal = Human Genetics

| volume = 122

| issue = 3–4

|date=November 2007

| doi = 10.1007/s00439-007-0383-6

| pages = 409–411

| pmid = 17653577

| s2cid = 13181665

}}

One study has found that the SNP may be associated with heroin addiction.{{Cite journal

| author = David A. Nielsen, Sandra Barral, Dmitri Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek

| title = TPH2 and TPH1: association of variants and interactions with heroin addiction

| journal = Behavior Genetics

| volume = 38

| issue = 2

| pages = 133–50

|date=March 2008

| doi = 10.1007/s10519-007-9187-7

| pmid = 18181017

| s2cid = 2774846

}} Other study relate it to figural and numeric creativity.{{Cite journal

| author = Reuter M, Roth S, Holve K & Hennig J.

| title = Identification of first candidate genes for creativity: a pilot study.

| journal = Brain Res.

| year = 2006

| volume = 1069

| issue = 1

| pages = 190–197

| doi = 10.1016/j.brainres.2005.11.046

| pmid = 16403463

| s2cid = 25365017

}}

A218C (rs1800532) is another SNP in the same intron in the same gene.