Rs5569

{{Infobox single nucleotide polymorphism

| rsid = 5569

| name_1 = A1287G

| name_2 = G1287A

| gene = SLC6A2

| region = Exon 9

| chromosome = 16

}}

In genetics, rs5569 (A1287G or G1287A) is a genetic variant.

It is a single nucleotide polymorphism (SNP) in the SLC6A2 gene in exon 9.

This gene codes the norepinephrine transporter.

The SNP is a silent substitution and

the nucleotides of both variants code a threonine amino acid.[https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?chooseRs=het&locusId=6530&mrna=NM_001043.2&ctg=NT_010498.15&prot=NP_001034.1&orien=forward&refresh=refresh dbSNP]

Several research studies have examined the effect of the variant in relation to alcohol dependence,{{Cite journal

| author = Jerzy Samochowiec, Jolanta Kucharska-Mazur, Ryszard Kaminski, Michael Smolka, Hans Rommelschpacher, Catrin Wernicke, Agnieszka Tymicz & Lutz Gerhardt Schmidt

| title = Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence

| journal = Psychiatry Research

| volume = 111

| issue = 2–3

| pages = 229–33

|date=August 2002

| pmid = 12374639

| doi = 10.1016/S0165-1781(02)00145-2

| s2cid = 6493515

}}{{Cite journal

| author = San-Yuan Huang, Ru-Band Lu, Kuo-Hsing Ma, Mee-Jen Shy & Wei-Wen Lin

| title = Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups

| journal = Drug and Alcohol Dependence

| volume = 92

| issue = 1–3

| pages = 20–26

|date=January 2008

| doi = 10.1016/j.drugalcdep.2007.06.003

| pmid = 17630229

}}

attention deficit hyperactivity disorder,{{Cite journal

| author = Soo-Churl Cho, Jae-Won Kim, Boong-Nyun Kim, Jun-Won Hwang, Mira Park, Soon Ae Kim, Dae-Yeon Cho, Hee-Jeong Yoo, Un-Sun Chung, Jung-Woo Son & Tae-Won Park

| title = No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample

| journal = Neuropsychobiology

| volume = 57

| issue = 3

| pages = 131–138

| year = 2008

| doi = 10.1159/000138916

| pmid = 18552510

| s2cid = 7062834

}}

diabetes,{{Cite journal

|author1=Piotr Ksiazek, Kinga Buraczynska |author2=Monika Buraczynska

|name-list-style=amp | title = Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes

| journal = Kidney and Blood Pressure Research

| volume = 29

| issue = 6

| pages = 338–43

| year = 2006

| doi = 10.1159/000097356

| pmid = 17124432

|s2cid=25727749

}}

major depressive disorder,{{Cite journal

| author = Peter Zill, Rolf Engel, Thomas C. Baghai, Georg Juckel, Thomas Frodl, Florian Muller-Siecheneder, Peter Zwanzger, Cornelius Schule, Christo Minov, Stefanie Behrens, Rainer Rupprecht, Ulrich Hegerl, Hans Jurgen Moller & Brigitta Bondy

| title = Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression

| journal = Neuropsychopharmacology

| volume = 26

| issue = 4

| pages = 489–93

|date=April 2002

| doi = 10.1016/S0893-133X(01)00386-4

| pmid = 11927173

| doi-access = free

}}{{Cite journal

| author = Kazuyuki Inoue, Kunihiko Itoh, Keizo Yoshida, Hisashi Higuchi, Mitsuhiro Kamata, Hitoshi Takahashi, Tetsuo Shimizu & Toshio Suzuki

| title = No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population

| journal = Biological & Pharmaceutical Bulletin

| volume = 30

| issue = 10

| pages = 1996–1998

|date=October 2007

| pmid = 17917281

| doi = 10.1248/bpb.30.1996

| doi-access = free

}}

panic disorder,{{Cite journal

| author = P. G. Sand, T. Mori, C. Godau, G. Stober, P. Flachenecker, P. Franke, M. M. Nothen, J. Fritze, W. Maier, K.-P. Lesch, P. Riederer, H. Beckmann & J. Deckert

| title = Norepinephrine transporter gene (NET) variants in patients with panic disorder

| journal = Neuroscience Letters

| volume = 333

| issue = 1

| pages = 41–44

|date=November 2002

| pmid = 12401556

| doi = 10.1016/S0304-3940(02)00984-9

| s2cid = 19657809

}}

Tourette syndrome{{Cite journal

| author = Christopher A. Rippel, Andrew J. Kobets, Dustin Y. Yoon, Phillip N. Williams, Yin Yao Shugart, Dana D. Bridges, David J. Vandenbergh & Harvey S. Singer

| title = Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association

| journal = Psychiatric Genetics

| volume = 16

| issue = 5

| pages = 179–80

|date=October 2006

| doi = 10.1097/01.ypg.0000218622.96127.71

| pmid = 16969268

}}

and personality traits.{{Cite journal

| author = J. Samochowiec, F. Rybakowski, P. Czerski, M. Zakrzewska, G. Stepien, J. Pelka-Wysiecka, J. Horodnicki, J. K. Rybakowski & J. Hauser

| title = Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers

| journal = Neuropsychobiology

| volume = 43

| issue = 4

| pages = 248–53

| year = 2001

| pmid = 11340364

| doi = 10.1159/000054898

| s2cid = 24521817

}}

None of the studies have found an association.