S-Glutathionylation

S-Glutathionylation is the posttranslational modification of protein cysteine residues by the addition of glutathione, the most abundant and important low-molecular-mass thiol within most cell types.{{cite journal

| doi=10.1016/j.tibs.2008.11.002

| title=Protein S-glutathionylation: A regulatory device from bacteria to humans

| year=2009

| last1=Dalle-Donne

| first1=Isabella

| last2=Rossi

| first2=Ranieri

| last3=Colombo

| first3=Graziano

| last4=Giustarini

| first4=Daniela

| last5=Milzani

| first5=Aldo

| journal=Trends in Biochemical Sciences

| volume=34

| issue=2

| pages=85–96

| pmid=19135374}}

Protein S-glutathionylation is involved in

• oxidative stress
• nitrosative stress
• preventing irreversible oxidation of protein thiols
• control of cell-signalling pathways by modulating protein function