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SART3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = August 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 | doi-access = free }}{{cite journal | vauthors = Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K | title = Mouse homologue of the human SART3 gene encoding tumor-rejection antigen | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 2 | pages = 239–47 | date = February 2000 | pmid = 10761712 | pmc = 5926322| doi = 10.1111/j.1349-7006.2000.tb00937.x }}{{cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733}}

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

Interactions

SART3 has been shown to interact with RNPS1{{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 | s2cid = 24724555 | doi-access = free }} and Androgen receptor.{{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 | doi-access = free }}

References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K | title = Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients | journal = Cancer Research | volume = 59 | issue = 16 | pages = 4056–63 | date = August 1999 | pmid = 10463607 }}
  • {{cite journal | vauthors = Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K | title = Expression of tumor-rejection antigens in gynecologic cancers | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 11 | pages = 1177–84 | date = November 2000 | pmid = 11092984 | pmc = 5926290 | doi = 10.1111/j.1349-7006.2000.tb00902.x }}
  • {{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 | s2cid = 24724555 | doi-access = free }}
  • {{cite journal | vauthors = Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K | title = Expression of tumor rejection antigens in colorectal carcinomas | journal = Cancer | volume = 94 | issue = 6 | pages = 1636–41 | date = March 2002 | pmid = 11920522 | doi = 10.1002/cncr.10421 | s2cid = 33045822 | doi-access = free }}
  • {{cite journal | vauthors = Liu Y, Li J, Kim BO, Pace BS, He JJ | title = HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23854–63 | date = June 2002 | pmid = 11959860 | doi = 10.1074/jbc.M200773200 | doi-access = free }}
  • {{cite journal | vauthors = Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A | title = p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2724–35 | date = June 2002 | pmid = 12032085 | pmc = 126028 | doi = 10.1093/emboj/21.11.2724 }}
  • {{cite journal | vauthors = Nottrott S, Urlaub H, Lührmann R | title = Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins | journal = The EMBO Journal | volume = 21 | issue = 20 | pages = 5527–38 | date = October 2002 | pmid = 12374753 | pmc = 129076 | doi = 10.1093/emboj/cdf544 }}
  • {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = November 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
  • {{cite journal | vauthors = Stanĕk D, Rader SD, Klingauf M, Neugebauer KM | title = Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies | journal = The Journal of Cell Biology | volume = 160 | issue = 4 | pages = 505–16 | date = February 2003 | pmid = 12578909 | pmc = 2173746 | doi = 10.1083/jcb.200210087 }}
  • {{cite journal | vauthors = Damianov A, Schreiner S, Bindereif A | title = Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP | journal = Molecular and Cellular Biology | volume = 24 | issue = 4 | pages = 1700–8 | date = February 2004 | pmid = 14749385 | pmc = 344176 | doi = 10.1128/MCB.24.4.1700-1708.2004 }}
  • {{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 | doi-access = free }}
  • {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
  • {{cite journal | vauthors = Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A | title = Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7392–401 | date = September 2004 | pmid = 15314151 | pmc = 506986 | doi = 10.1128/MCB.24.17.7392-7401.2004 }}
  • {{cite journal | vauthors = Stanĕk D, Neugebauer KM | title = Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer | journal = The Journal of Cell Biology | volume = 166 | issue = 7 | pages = 1015–25 | date = September 2004 | pmid = 15452143 | pmc = 2172029 | doi = 10.1083/jcb.200405160 }}

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{{PDB Gallery|geneid=9733}}

Category:Spliceosome

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