SAS-1121
{{Short description|Compound which binds to the sigma-2 receptor, a cell-membrane protein}}
{{Multiple issues|
{{context|date=August 2017}}
{{technical|date=August 2017}}}}
SAS-1121 is an organic molecule which binds to a specific protein, the sigma-2 receptor, found in cell membranes. It is highly selective for this over the related sigma-1 receptor. The sigma-2 receptor is significant in cancer and some neurological illnesses.
These two receptors are cell surface receptors: proteins in a cell membrane which pass a signal to the cell when some external molecule binds to them.
SAS-1121 is 280-fold selective for the sigma 2 receptor (Ki = 23.8 nM) {{technical inline|date=March 2024}} over the sigma 1 receptor (Ki = 6659.6 nM),{{technical inline|date=March 2024}}{{Cite journal|last1=Sahn|first1=James J.|last2=Hodges|first2=Timothy R.|last3=Chan|first3=Jessica Z.|last4=Martin|first4=Stephen F.|date=2017-04-13|title=Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity|journal=ACS Medicinal Chemistry Letters|volume=8|issue=4|pages=455–460|doi=10.1021/acsmedchemlett.7b00066|pmc=5392765|pmid=28435536}} and served as a tool compound to help identify the sigma 2 receptor as transmembrane 97 (TMEM97).{{Cite journal|last1=Alon|first1=Assaf|last2=Schmidt|first2=Hayden R.|last3=Wood|first3=Michael D.|last4=Sahn|first4=James J.|last5=Martin|first5=Stephen F.|last6=Kruse|first6=Andrew C.|date=2017-05-30|title=Identification of the gene that codes for the σ2 receptor|journal=Proceedings of the National Academy of Sciences|language=en|pages=7160–7165|doi=10.1073/pnas.1705154114|issn=0027-8424|pmid=28559337|volume=114|issue=27|pmc=5502638|doi-access=free}}
SAS-1121 is classed as a norbenzomorphan-piperazine.
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