SAV1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.{{cite journal | vauthors = Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK | title = salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines | journal = Cell | volume = 110 | issue = 4 | pages = 467–78 |date=Aug 2002 | pmid = 12202036 | doi =10.1016/S0092-8674(02)00824-3 | doi-access = free }}{{cite journal | author = Valverde P | title = Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene | journal = Biochem Biophys Res Commun | volume = 276 | issue = 3 | pages = 990–8 |date=Oct 2000 | pmid = 11027580 | doi = 10.1006/bbrc.2000.3582 | s2cid = 22968498 }}
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.{{cite web | title = SAV1 salvador family WW domain containing protein 1 [ Homo sapiens (human) ]| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60485}}
References
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Further reading
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- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Yoo NJ, Soung YH, Lee JW, etal |title=Mutational analysis of salvador gene in human carcinomas |journal=APMIS |volume=111 |issue= 6 |pages= 595–8 |year= 2003 |pmid= 12969014 |doi=10.1034/j.1600-0463.2003.1110601.x |s2cid=43269337 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Chan EH, Nousiainen M, Chalamalasetty RB, etal |title=The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 |journal=Oncogene |volume=24 |issue= 12 |pages= 2076–86 |year= 2005 |pmid= 15688006 |doi= 10.1038/sj.onc.1208445 |s2cid=27285160 }}
- {{cite journal |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |doi-access= free }}
- {{cite journal | vauthors=Callus BA, Verhagen AM, Vaux DL |title=Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation |journal=FEBS J. |volume=273 |issue= 18 |pages= 4264–76 |year= 2006 |pmid= 16930133 |doi= 10.1111/j.1742-4658.2006.05427.x |doi-access= |s2cid=8261982 }}
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{{PDB Gallery|geneid=60485}}
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