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SCAMP3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.{{cite journal | vauthors = Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E | title = Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease | journal = Genome Research | volume = 7 | issue = 10 | pages = 1020–6 | date = October 1997 | pmid = 9331372 | pmc = 310674 | doi = 10.1101/gr.7.10.1020 }}{{cite journal | vauthors = Wu TT, Castle JD | title = Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor | journal = Molecular Biology of the Cell | volume = 9 | issue = 7 | pages = 1661–74 | date = July 1998 | pmid = 9658162 | pmc = 25404 | doi = 10.1091/mbc.9.7.1661 }}{{cite web | title = Entrez Gene: SCAMP3 secretory carrier membrane protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10067}}

Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

SCAMP3 has been shown to interact with NEDD4.{{cite journal | vauthors = Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD | title = SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling | journal = Molecular Biology of the Cell | volume = 20 | issue = 6 | pages = 1816–32 | date = March 2009 | pmid = 19158374 | pmc = 2655259 | doi = 10.1091/mbc.E08-09-0894 }}

References

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Further reading

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  • {{cite journal | vauthors = Wu TT, Castle JD | title = Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs) | journal = Journal of Cell Science | volume = 110 ( Pt 13) | issue = 13 | pages = 1533–41 | date = July 1997 | doi = 10.1242/jcs.110.13.1533 | pmid = 9224770 }}
  • {{cite journal | vauthors = Singleton DR, Wu TT, Castle JD | title = Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions | journal = Journal of Cell Science | volume = 110 ( Pt 17) | issue = 17 | pages = 2099–107 | date = September 1997 | doi = 10.1242/jcs.110.17.2099 | pmid = 9378760 }}
  • {{cite journal | vauthors = Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC | title = SCAMP1 function in endocytosis | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12752–6 | date = April 2000 | pmid = 10777571 | doi = 10.1074/jbc.275.17.12752 | doi-access = free }}
  • {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
  • {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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External links

  • {{UCSC genome browser|SCAMP3}}
  • {{UCSC gene details|SCAMP3}}

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