SCG2

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.{{cite web | title = Entrez Gene: SCG2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7857 }}

• Chromogranin

{{refbegin | 2}}

• {{cite journal |vauthors=Kirchmair R, Gander R, Egger M, etal |title=The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo. |journal=Circulation |volume=109 |issue= 6 |pages= 777–83 |year= 2004 |pmid= 14970115 |doi= 10.1161/01.CIR.0000112574.07422.C1 |doi-access= free }}
• {{cite journal |vauthors=Ozawa H, Takata K |title=The granin family--its role in sorting and secretory granule formation. |journal=Cell Struct. Funct. |volume=20 |issue= 6 |pages= 415–20 |year= 1995 |pmid= 8825061 |doi=10.1247/csf.20.415 |doi-access=free }}
• {{cite journal |vauthors=Huttner WB, Gerdes HH, Rosa P |title=The granin (chromogranin/secretogranin) family. |journal=Trends Biochem. Sci. |volume=16 |issue= 1 |pages= 27–30 |year= 1991 |pmid= 2053134 |doi=10.1016/0968-0004(91)90012-K }}
• {{cite journal |vauthors=Stemberger K, Pallhuber J, Doblinger A, etal |title=Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels. |journal=Peptides |volume=25 |issue= 12 |pages= 2115–8 |year= 2004 |pmid= 15572199 |doi= 10.1016/j.peptides.2004.08.010 |s2cid=21826451 }}
• {{cite journal |vauthors=Scammell JG, Reddy S, Valentine DL, etal |title=Isolation and characterization of the human secretogranin II gene promoter. |journal=Brain Res. Mol. Brain Res. |volume=75 |issue= 1 |pages= 8–15 |year= 2000 |pmid= 10648883 |doi=10.1016/S0169-328X(99)00269-7 }}
• {{cite journal |vauthors=Kähler CM, Schratzberger P, Kaufmann G, etal |title=Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin. |journal=Regul. Pept. |volume=105 |issue= 1 |pages= 35–46 |year= 2002 |pmid= 11853870 |doi=10.1016/S0167-0115(01)00379-2 |s2cid=6144086 }}
• {{cite journal |vauthors=Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F |title=Phosphoproteomic analysis of the human pituitary. |journal=Pituitary |volume=9 |issue= 2 |pages= 109–20 |year= 2006 |pmid= 16807684 |doi= 10.1007/s11102-006-8916-x |s2cid=10789246 }}
• {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |doi-access=free }}
• {{cite journal |vauthors=Kato A, Kammen-Jolly K, Fischer-Colbie R, etal |title=Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. |journal=Brain Res. |volume=852 |issue= 2 |pages= 444–52 |year= 2000 |pmid= 10678772 |doi=10.1016/S0006-8993(99)02229-5 |s2cid=22936622 }}
• {{cite journal |vauthors=Schrott-Fischer A, Bitsche M, Humpel C, etal |title=Chromogranin peptides in amyotrophic lateral sclerosis. |journal=Regul. Pept. |volume=152 |issue= 1–3 |pages= 13–21 |year= 2009 |pmid= 18721831 |doi= 10.1016/j.regpep.2008.07.009 |s2cid=207494362 }}
• {{cite journal |vauthors=Fischer-Colbrie R, Kirchmair R, Kähler CM, etal |title=Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. |journal=Curr. Protein Pept. Sci. |volume=6 |issue= 4 |pages= 373–85 |year= 2005 |pmid= 16101435 |doi=10.2174/1389203054546334 }}
• {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
• {{cite journal |vauthors=Lankat-Buttgereit B, Müller S, Schmidt H, etal |title=Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line. |journal=Biol. Cell |volume=100 |issue= 12 |pages= 703–15 |year= 2008 |pmid= 18549351 |doi= 10.1042/BC20080052 |s2cid=8007910 |doi-access= }}
• {{cite journal |vauthors=Stridsberg M, Eriksson B, Janson ET |title=Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. |journal=Regul. Pept. |volume=148 |issue= 1–3 |pages= 95–8 |year= 2008 |pmid= 18448176 |doi= 10.1016/j.regpep.2008.03.007 |s2cid=24853860 }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
• {{cite journal |vauthors=Wen G, Wessel J, Zhou W, etal |title=An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. |journal=Hum. Mol. Genet. |volume=16 |issue= 14 |pages= 1752–64 |year= 2007 |pmid= 17584765 |doi= 10.1093/hmg/ddm123 |pmc=2695823 }}
• {{cite journal |vauthors=Yon L, Guillemot J, Montero-Hadjadje M, etal |title=Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2579–85 |year= 2003 |pmid= 12788858 |doi=10.1210/jc.2002-021748 |doi-access=free }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Wu C, Ma MH, Brown KR, etal |title=Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. |journal=Proteomics |volume=7 |issue= 11 |pages= 1775–85 |year= 2007 |pmid= 17474147 |doi= 10.1002/pmic.200601006 |s2cid=22474278 }}
• {{cite journal |vauthors=Li L, Hung AC, Porter AG |title=Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells. |journal=Cell Death Differ. |volume=15 |issue= 5 |pages= 879–88 |year= 2008 |pmid= 18239671 |doi= 10.1038/cdd.2008.8 |s2cid=205116721 }}

{{refend}}

{{Reflist}}

{{NLM content}}

{{gene-2-stub}}